5EZD

Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue K A 401

Chain	Residue
A	GLU293
A	GLU294
A	HOH524

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site_id	AC2
Number of Residues	4
Details	binding site for residue ACT B 401

Chain	Residue
A	VAL256
A	GLY261
B	SER277
B	HOH510

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ACT B 402

Chain	Residue
B	GLY261
B	HOH512
A	SER277
B	VAL256

---

site_id	AC4
Number of Residues	3
Details	binding site for residue K B 403

Chain	Residue
B	GLU293
B	GLU294
B	HOH526

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Functional Information from PROSITE/UniProt

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FvyGGClgnknnYlreeeC

Chain	Residue	Details
A	PHE278-CYS296

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"BPTI/Kunitz inhibitor 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Reactive bond","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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