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PDB: 21 件
5TXI
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BU of 5txi by Molmil
Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with ceftobiprole
分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2016-11-16
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
6DZ8
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BU of 6dz8 by Molmil
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (S75C)
分子名称: Penicillin-binding protein 4, ZINC ION
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2018-07-03
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Recognition of Peptidoglycan Fragments by the Transpeptidase PBP4 FromStaphylococcus aureus.
Front Microbiol, 9, 2018
7KCW
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BU of 7kcw by Molmil
Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with nafcillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL, Penicillin-binding protein 4, ...
著者Alexander, J.A, Strynadka, N.C.
登録日2020-10-07
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
J.Antimicrob.Chemother., 76, 2021
6C39
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BU of 6c39 by Molmil
Apo crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4)
分子名称: SODIUM ION, SULFATE ION, Serine-type D-Ala-D-Ala carboxypeptidase, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2018-01-09
公開日2018-11-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 293, 2018
6C3K
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BU of 6c3k by Molmil
Apo crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R)
分子名称: CHLORIDE ION, Penicillin-binding protein 4, SODIUM ION, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2018-01-10
公開日2018-11-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 293, 2018
7KCX
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BU of 7kcx by Molmil
Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with cefoxitin
分子名称: (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, Penicillin-binding protein 4, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2020-10-07
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
J.Antimicrob.Chemother., 76, 2021
7KCV
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BU of 7kcv by Molmil
Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L)
分子名称: Penicillin-binding protein 4, ZINC ION
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2020-10-07
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
J.Antimicrob.Chemother., 76, 2021
7KCY
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BU of 7kcy by Molmil
Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) with cefoxitin
分子名称: (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, Penicillin-binding protein 4, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2020-10-07
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
J.Antimicrob.Chemother., 76, 2021
6O9S
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Crystal structure of Staphylococcus aureus MecR1 antibiotic-sensor domain in complex with avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Methicillin resistance mecR1 protein, SULFATE ION
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2019-03-14
公開日2020-06-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus .
J.Biol.Chem., 295, 2020
6O9W
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BU of 6o9w by Molmil
Crystal structure of Staphylococcus aureus BlaR1 antibiotic-sensor domain in complex with avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Regulatory protein BlaR1
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2019-03-15
公開日2020-06-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus .
J.Biol.Chem., 295, 2020
5TW4
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BU of 5tw4 by Molmil
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with ceftaroline
分子名称: CHLORIDE ION, Ceftaroline, bound form, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2016-11-11
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
5TY7
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BU of 5ty7 by Molmil
Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with nafcillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Penicillin-binding protein 4, SODIUM ION, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2016-11-18
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.894 Å)
主引用文献Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
5TW8
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BU of 5tw8 by Molmil
Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with ceftaroline
分子名称: Ceftaroline, bound form, Penicillin-binding protein 4, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2016-11-11
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
5TX9
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BU of 5tx9 by Molmil
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with ceftobiprole
分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Penicillin-binding protein 4, SODIUM ION, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2016-11-16
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
5TY2
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BU of 5ty2 by Molmil
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, Penicillin-binding protein 4, ...
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2016-11-18
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
8EXS
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BU of 8exs by Molmil
Cryo-EM structure of S. aureus BlaR1 F284A mutant
分子名称: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
著者Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J.
登録日2022-10-25
公開日2023-01-11
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXT
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BU of 8ext by Molmil
Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin
分子名称: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
著者Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J.
登録日2022-10-25
公開日2023-01-11
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
6XFU
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BU of 6xfu by Molmil
PmtCD peptide exporter basket domain
分子名称: ABC transporter ATP-binding protein, THIOCYANATE ION
著者Zeytuni, N, Strynadka, N.C.J, Alexander, J.A.N.
登録日2020-06-16
公開日2020-10-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural insight into the Staphylococcus aureus ATP-driven exporter of virulent peptide toxins
Sci Adv, 6, 2020
8EXR
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BU of 8exr by Molmil
Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain
分子名称: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ...
著者Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
登録日2022-10-25
公開日2023-01-11
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXQ
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BU of 8exq by Molmil
Cryo-EM structure of S. aureus BlaR1 with C1 symmetry
分子名称: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
著者Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
登録日2022-10-25
公開日2023-01-11
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXP
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BU of 8exp by Molmil
Cryo-EM structure of S. aureus BlaR1 with C2 symmetry
分子名称: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
著者Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
登録日2022-10-25
公開日2023-01-11
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023

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