7KCX

Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with cefoxitin

Summary for 7KCX

Entry DOI	10.2210/pdb7kcx/pdb
Descriptor	Penicillin-binding protein 4, (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, ... (5 entities in total)
Functional Keywords	acyl-enzyme intermediate, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Staphylococcus aureus (strain COL)
Total number of polymer chains	1
Total formula weight	41672.34
Authors	Alexander, J.A.N.,Strynadka, N.C.J. (deposition date: 2020-10-07, release date: 2021-06-30, Last modification date: 2023-10-18)
Primary citation	Satishkumar, N.,Alexander, J.A.N.,Poon, R.,Buggeln, E.,Argudin, M.A.,Strynadka, N.C.J.,Chatterjee, S.S. PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus. J.Antimicrob.Chemother., 76:2268-2272, 2021 Cited by PubMed: 34151961 DOI: 10.1093/jac/dkab201 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation