8DYT
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![BU of 8dyt by Molmil](/molmil-images/mine/8dyt) | Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide | Descriptor: | 227 Fab heavy chain, 227 Fab light chain, Circumsporozoite protein | Authors: | Martin, G.M, Ward, A.B. | Deposit date: | 2022-08-05 | Release date: | 2023-08-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023
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5LOS
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![BU of 5los by Molmil](/molmil-images/mine/5los) | Piriformospora indica PIIN_05872 | Descriptor: | PIIN_05872, SULFATE ION, ZINC ION | Authors: | Hartmann, M.D, Albrecht, R, Martin, J, Lupas, A.N. | Deposit date: | 2016-08-09 | Release date: | 2018-05-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A secreted fungal histidine- and alanine-rich protein regulates metal ion homeostasis and oxidative stress. New Phytol., 227, 2020
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6R85
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![BU of 6r85 by Molmil](/molmil-images/mine/6r85) | Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-glutamate | Descriptor: | 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutamate receptor 3.3,Glutamate receptor 3.3, ... | Authors: | Alfieri, A, Pederzoli, R, Costa, A. | Deposit date: | 2019-03-31 | Release date: | 2020-01-01 | Last modified: | 2020-01-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
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8E5R
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![BU of 8e5r by Molmil](/molmil-images/mine/8e5r) | Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0150610 Complex | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein, [4-({[(3R)-1-[(1H-indol-3-yl)methyl]-3-{[4-(trifluoromethyl)phenyl]methyl}pyrrolidin-3-yl]methyl}amino)-3-nitrophenyl]methanol | Authors: | Taylor, A.B, Alwan, S.N. | Deposit date: | 2022-08-22 | Release date: | 2023-07-26 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. Plos Pathog., 19, 2023
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5LQ4
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![BU of 5lq4 by Molmil](/molmil-images/mine/5lq4) | The Structure of ThcOx, the First Oxidase Protein from the Cyanobactin Pathways | Descriptor: | CyaGox, FLAVIN MONONUCLEOTIDE | Authors: | Bent, A.F, Wagner, A, Naismith, J.H. | Deposit date: | 2016-08-16 | Release date: | 2016-11-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD. Acta Crystallogr D Struct Biol, 72, 2016
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4XEJ
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![BU of 4xej by Molmil](/molmil-images/mine/4xej) | IRES bound to bacterial Ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Zhu, J, Korostelev, A, Noller, H.F, Donohue, J.P. | Deposit date: | 2014-12-23 | Release date: | 2015-02-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Initiation of translation in bacteria by a structured eukaryotic IRES RNA. Nature, 519, 2015
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5LSG
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![BU of 5lsg by Molmil](/molmil-images/mine/5lsg) | PPARgamma complex with the betulinic acid | Descriptor: | Betulinic Acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Calleri, E, Paiardini, A. | Deposit date: | 2016-08-26 | Release date: | 2017-08-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Betulinic acid is a PPAR gamma antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis. Sci Rep, 7, 2017
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7SKI
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![BU of 7ski by Molmil](/molmil-images/mine/7ski) | Pertussis toxin in complex with PJ34 | Descriptor: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Pertussis toxin subunit 1 | Authors: | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | Deposit date: | 2021-10-20 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.09912443 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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6XZ8
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![BU of 6xz8 by Molmil](/molmil-images/mine/6xz8) | Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1-[5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3-pyridyl]ethyl]methanesulfonamide | Descriptor: | Cytochrome P450 11B2, mitochondrial, HEME C, ... | Authors: | Kuglstatter, A, Joseph, C, Benz, J. | Deposit date: | 2020-02-03 | Release date: | 2020-06-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020
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8E5Q
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![BU of 8e5q by Molmil](/molmil-images/mine/8e5q) | Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0150303 Complex | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein, [2-(dihydroxyamino)-4-({[(3R)-1-[(1H-indol-3-yl)methyl]-3-{[3-(trifluoromethyl)phenyl]methyl}pyrrolidin-3-yl]methyl}amino)phenyl]methanol | Authors: | Taylor, A.B, Alwan, S.N. | Deposit date: | 2022-08-22 | Release date: | 2023-07-26 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. Plos Pathog., 19, 2023
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6UJC
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![BU of 6ujc by Molmil](/molmil-images/mine/6ujc) | Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6-RGD3 heavy chain Fab, ... | Authors: | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | Deposit date: | 2019-10-02 | Release date: | 2020-02-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
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6R8T
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![BU of 6r8t by Molmil](/molmil-images/mine/6r8t) | Crystal structure of aIF2gamma subunit I181T from archaeon Sulfolobus solfataricus complexed with GDPCP | Descriptor: | FORMIC ACID, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Kravchenko, O, Arkhipova, V, Gabdulkhakov, A, Stolboushkina, E, Nikonov, O, Garber, M, Nikonov, S. | Deposit date: | 2019-04-02 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of aIF2gamma subunit I181T from archaeon Sulfolobus solfataricus complexed with GDPCP To Be Published
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6ZVP
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![BU of 6zvp by Molmil](/molmil-images/mine/6zvp) | Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms | Descriptor: | FE (III) ION, L-DOPAMINE, Tyrosine 3-monooxygenase | Authors: | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | Deposit date: | 2020-07-27 | Release date: | 2021-11-17 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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4XTR
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![BU of 4xtr by Molmil](/molmil-images/mine/4xtr) | Structure of Get3 bound to the transmembrane domain of Pep12 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | Deposit date: | 2015-01-23 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science, 347, 2015
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7SKY
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![BU of 7sky by Molmil](/molmil-images/mine/7sky) | Pertussis toxin S1 bound to NAD+ | Descriptor: | IODIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pertussis toxin subunit 1 | Authors: | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | Deposit date: | 2021-10-21 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.37000132 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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4X9S
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![BU of 4x9s by Molmil](/molmil-images/mine/4x9s) | CRYSTAL STRUCTURE OF HISAP FROM STREPTOMYCES SP. MG1 | Descriptor: | Phosphoribosyl isomerase A, SULFATE ION | Authors: | MICHALSKA, K, VERDUZCO-CASTRO, E.A, ENDRES, M, BARONA-GOMEZ, F, JOACHIMIAK, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-12-11 | Release date: | 2014-12-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
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6R72
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![BU of 6r72 by Molmil](/molmil-images/mine/6r72) | Crystal structure of BmrA-E504A in an outward-facing conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug exporter ATP-binding cassette | Authors: | Chaptal, V, Zampieri, V, Kilburg, A, Magnard, S, Falson, P. | Deposit date: | 2019-03-28 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.95 Å) | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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8BV3
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![BU of 8bv3 by Molmil](/molmil-images/mine/8bv3) | Bacillus subtilis DnaA domain III structure | Descriptor: | Chromosomal replication initiator protein DnaA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Pintar, S, Hubbard, J.A. | Deposit date: | 2022-12-01 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | The bacterial replication origin BUS promotes nucleobase capture. Nat Commun, 14, 2023
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8DYW
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![BU of 8dyw by Molmil](/molmil-images/mine/8dyw) | |
6R7U
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![BU of 6r7u by Molmil](/molmil-images/mine/6r7u) | Selenomethionine variant of Tannerella forsythia promirolysin mutant E225A | Descriptor: | BORIC ACID, CALCIUM ION, GLYCEROL, ... | Authors: | Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X. | Deposit date: | 2019-03-29 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases. Iucrj, 7, 2020
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6ZN2
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![BU of 6zn2 by Molmil](/molmil-images/mine/6zn2) | Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding. | Descriptor: | FE (III) ION, L-DOPAMINE, SER-LEU-ILE-GLU-ASP-ALA-ARG-LYS-GLU-ARG-GLU-ALA-ALA-VAL-ALA-ALA-ALA-ALA, ... | Authors: | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | Deposit date: | 2020-07-06 | Release date: | 2021-12-08 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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8DYY
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![BU of 8dyy by Molmil](/molmil-images/mine/8dyy) | |
8DZ3
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![BU of 8dz3 by Molmil](/molmil-images/mine/8dz3) | |
5IGZ
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![BU of 5igz by Molmil](/molmil-images/mine/5igz) | |
6X9T
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![BU of 6x9t by Molmil](/molmil-images/mine/6x9t) | |