8DYT

Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide

Summary for 8DYT

Entry DOI	10.2210/pdb8dyt/pdb
EMDB information	27781
Descriptor	Circumsporozoite protein, 227 Fab light chain, 227 Fab heavy chain (3 entities in total)
Functional Keywords	malaria antibody, pfcsp, immune system
Biological source	Plasmodium falciparum 3D7 More
Total number of polymer chains	18
Total formula weight	588486.20
Authors	Martin, G.M.,Ward, A.B. (deposition date: 2022-08-05, release date: 2023-08-02, Last modification date: 2024-04-24)
Primary citation	Martin, G.M.,Torres, J.L.,Pholcharee, T.,Oyen, D.,Flores-Garcia, Y.,Gibson, G.,Moskovitz, R.,Beutler, N.,Jung, D.D.,Copps, J.,Lee, W.H.,Gonzalez-Paez, G.,Emerling, D.,MacGill, R.S.,Locke, E.,King, C.R.,Zavala, F.,Wilson, I.A.,Ward, A.B. Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14:4546-4546, 2023 Cited by PubMed: 37507365 DOI: 10.1038/s41467-023-40151-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation