6MWG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mwg by Molmil](/molmil-images/mine/6mwg) | NavAb Voltage-gated Sodium Channel, residues 1-239, with mutation T206V | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ACETATE ION, ... | 著者 | Lenaeus, M.J, Catterall, W.A. | 登録日 | 2018-10-29 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
|
|
4Y36
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4y36 by Molmil](/molmil-images/mine/4y36) | Endothiapepsin in complex with fragment 4 | 分子名称: | 1,2-ETHANEDIOL, 3-methylbenzohydrazide, Endothiapepsin, ... | 著者 | Radeva, N, Uehlein, M, Weiss, M.S, Heine, A, Klebe, G. | 登録日 | 2015-02-10 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Crystallographic Fragment Screening of an Entire Library To Be Published
|
|
6MX7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mx7 by Molmil](/molmil-images/mine/6mx7) | CryoEM structure of chimeric Eastern Equine Encephalitis Virus: Genome-Binding Capsid N-terminal Domain | 分子名称: | Capsid | 著者 | Hasan, S.S, Sun, C, Kim, A.S, Watanabe, Y, Chen, C.L, Klose, T, Buda, G, Crispin, M, Diamond, M.S, Klimstra, W.B, Rossmann, M.G. | 登録日 | 2018-10-30 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization. Cell Rep, 25, 2018
|
|
6F5K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6f5k by Molmil](/molmil-images/mine/6f5k) | Crystal structure of laccase from Myceliophthora thermophila | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Ernst, H.A, Joergensen, L.J, Piontek, K, Bukh, C, Oestergaard, L.H, Larsen, S, Bjerrum, M.J. | 登録日 | 2017-12-01 | 公開日 | 2018-12-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | A comparative structural analysis of the surface properties of asco-laccases. Plos One, 13, 2018
|
|
6SC2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sc2 by Molmil](/molmil-images/mine/6sc2) | Structure of the dynein-2 complex; IFT-train bound model | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 2 light intermediate chain 1, ... | 著者 | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | 登録日 | 2019-07-23 | 公開日 | 2019-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
|
|
7T9Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t9z by Molmil](/molmil-images/mine/7t9z) | |
6SEI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sei by Molmil](/molmil-images/mine/6sei) | Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease | 分子名称: | CALCIUM ION, DNA (32-MER), Structure-specific endonuclease subunit SLX1, ... | 著者 | Gaur, V, Zajko, W, Nirwal, S, Szlachcic, A, Gapinska, M, Nowotny, M. | 登録日 | 2019-07-30 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease. Nucleic Acids Res., 47, 2019
|
|
5MUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mup by Molmil](/molmil-images/mine/5mup) | Structure of deformed wing virus, a honeybee pathogen | 分子名称: | URIDINE-5'-MONOPHOSPHATE, VP1, VP2, ... | 著者 | Skubnik, K, Novacek, J, Fuzik, T, Pridal, A, Paxton, R, Plevka, P. | 登録日 | 2017-01-13 | 公開日 | 2017-04-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of deformed wing virus, a major honey bee pathogen. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
7TA1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ta1 by Molmil](/molmil-images/mine/7ta1) | Human Ornithine Aminotransferase (hOAT) soaked with gamma-Aminobutyric acid | 分子名称: | 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID, Ornithine aminotransferase, mitochondrial, ... | 著者 | Butrin, A, Wawrzak, Z, Liu, D. | 登録日 | 2021-12-20 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase. J.Biol.Chem., 298, 2022
|
|
5JOP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jop by Molmil](/molmil-images/mine/5jop) | Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A | 分子名称: | Fab 14.22 light chain, Fab14.22 heavy chain, GLYCEROL, ... | 著者 | Sarkar, A, Irimia, A, Teyton, L, Wilson, I.A. | 登録日 | 2016-05-02 | 公開日 | 2017-03-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | T cells control the generation of nanomolar-affinity anti-glycan antibodies. J. Clin. Invest., 127, 2017
|
|
7QGI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qgi by Molmil](/molmil-images/mine/7qgi) | Crystal structure of SARS-CoV-2 NSP14 in the absence of NSP10 | 分子名称: | PHOSPHATE ION, Proofreading exoribonuclease nsp14, ZINC ION | 著者 | Newman, J.A, Imprachim, N, Yosaatmadja, Y, Gileadi, O. | 登録日 | 2021-12-08 | 公開日 | 2022-01-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development. Nucleic Acids Res., 51, 2023
|
|
7QGP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qgp by Molmil](/molmil-images/mine/7qgp) | STK10 (LOK) bound to Macrocycle CKJB51 | 分子名称: | 1,2-ETHANEDIOL, 1-[(4-chloranyl-2-methyl-phenyl)methyl]-3-(7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaen-5-yl)urea, CHLORIDE ION, ... | 著者 | Berger, B.-T, Schroeder, M, Kraemer, A, Schwalm, M.P, Kurz, C.G, Amrhein, J.A, Hanke, T, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-12-09 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | STK10 bound to CKJB51 To Be Published
|
|
5JP2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jp2 by Molmil](/molmil-images/mine/5jp2) | |
6FBD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fbd by Molmil](/molmil-images/mine/6fbd) | KlenTaq DNA polymerase processing a modified primer - bearing the modification upstream at the second primer nucleotide. | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*AP*(OH3)P*C)-3'), DNA (5'-D(P*AP*AP*AP*CP*GP*GP*TP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... | 著者 | Kropp, H.M, Diederichs, K, Marx, A. | 登録日 | 2017-12-19 | 公開日 | 2018-09-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7QIF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qif by Molmil](/molmil-images/mine/7qif) | Crystal structure of SARS-CoV-2 NSP14 in complex with 7MeGpppG. | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ... | 著者 | Newman, J.A, Imprachim, N, Yosaatmadja, Y, Gileadi, O. | 登録日 | 2021-12-14 | 公開日 | 2022-02-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development. Nucleic Acids Res., 51, 2023
|
|
5MV5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mv5 by Molmil](/molmil-images/mine/5mv5) | Structure of deformed wing virus, a honeybee pathogen | 分子名称: | URIDINE-5'-MONOPHOSPHATE, VP1, VP2, ... | 著者 | Skubnik, K, Novacek, J, Fuzik, T, Pridal, A, Paxton, R, Plevka, P. | 登録日 | 2017-01-15 | 公開日 | 2017-04-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of deformed wing virus, a major honey bee pathogen. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
6P6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6p6s by Molmil](/molmil-images/mine/6p6s) | HCV NS3/4A protease domain of genotype 3a in complex with glecaprevir | 分子名称: | (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, 1,2-ETHANEDIOL, ... | 著者 | Timm, J, Schiffer, C.A. | 登録日 | 2019-06-04 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences To Be Published
|
|
5MMN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mmn by Molmil](/molmil-images/mine/5mmn) | E. coli DNA Gyrase B 24 kDa ATPase domain in complex with 1-ethyl-3-[8-methyl-5-(2-methyl-pyridin-4-yl)-isoquinolin-3-yl]-urea | 分子名称: | 1-ethyl-3-[8-methyl-5-(2-methylpyridin-4-yl)isoquinolin-3-yl]urea, DNA gyrase subunit B | 著者 | Panchaud, P, Bruyere, T, Blumstein, A.-C, Bur, D, Chambovey, A, Ertel, E.A, Gude, M, Hubschwerlen, C, Jacob, L, Kimmerlin, T, Pfeifer, T, Prade, L, Seiler, P, Ritz, D, Rueedi, G. | 登録日 | 2016-12-12 | 公開日 | 2017-04-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. J. Med. Chem., 60, 2017
|
|
6MWA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mwa by Molmil](/molmil-images/mine/6mwa) | NavAb Voltage-gated Sodium Channel, residues 1-239 | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ... | 著者 | Lenaeus, M.J, Catterall, W.A. | 登録日 | 2018-10-29 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
|
|
6F8H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6f8h by Molmil](/molmil-images/mine/6f8h) | antitoxin GraA | 分子名称: | XRE family transcriptional regulator | 著者 | Talavera, A, Loris, R. | 登録日 | 2017-12-13 | 公開日 | 2019-01-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nat Commun, 10, 2019
|
|
6V5M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6v5m by Molmil](/molmil-images/mine/6v5m) | Crystal Structure of Metallo Beta Lactamase from Hirschia baltica in Complex with Succinate | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase, ... | 著者 | Maltseva, N, Kim, Y, Clancy, S, Endres, M, Mulligan, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-12-04 | 公開日 | 2019-12-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of Metallo Beta Lactamase from Hirschia baltica in Complex with Succinate. To Be Published
|
|
7TBD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tbd by Molmil](/molmil-images/mine/7tbd) | Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM382 | 分子名称: | (4R)-4-[(2E)-4,4-diethyl-2-imino-6-oxo-1,3-diazinan-1-yl]-N-[(4S)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Hodder, A.N, Christensen, J.B, Scally, S.W, Cowman, A.F. | 登録日 | 2021-12-21 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax. Structure, 30, 2022
|
|
4Y3M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4y3m by Molmil](/molmil-images/mine/4y3m) | |
7QE7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qe7 by Molmil](/molmil-images/mine/7qe7) | High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | 登録日 | 2021-12-01 | 公開日 | 2022-01-26 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
|
|
6FE3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fe3 by Molmil](/molmil-images/mine/6fe3) | Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1439 | 分子名称: | 1-(2-{4-[(4aS,8aR)-4-[3,4-bis(difluoromethoxy)phenyl]-1-oxo-1,2,4a,5,8,8a-hexahydrophthalazin-2-yl]piperidin-1-yl}-2-oxoethyl)-4,4-dimethylpiperidine-2,6-dione, FORMIC ACID, GLYCEROL, ... | 著者 | Singh, A.K, Brown, D.G. | 登録日 | 2017-12-28 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | TbrPDEB1 structure with inhibitor NPD-1439 To be published
|
|