7QIF
Crystal structure of SARS-CoV-2 NSP14 in complex with 7MeGpppG.
Summary for 7QIF
Entry DOI | 10.2210/pdb7qif/pdb |
Descriptor | Proofreading exoribonuclease nsp14, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, ZINC ION, ... (5 entities in total) |
Functional Keywords | nsp14, sars-cov-2, nuclease, methyltransferase, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 1 |
Total formula weight | 60723.78 |
Authors | Newman, J.A.,Imprachim, N.,Yosaatmadja, Y.,Gileadi, O. (deposition date: 2021-12-14, release date: 2022-02-02, Last modification date: 2024-02-07) |
Primary citation | Imprachim, N.,Yosaatmadja, Y.,Newman, J.A. Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development. Nucleic Acids Res., 51:475-487, 2023 Cited by PubMed: 36546776DOI: 10.1093/nar/gkac1207 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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