7QIF

Crystal structure of SARS-CoV-2 NSP14 in complex with 7MeGpppG.

Summary for 7QIF

Entry DOI	10.2210/pdb7qif/pdb
Descriptor	Proofreading exoribonuclease nsp14, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, ZINC ION, ... (5 entities in total)
Functional Keywords	nsp14, sars-cov-2, nuclease, methyltransferase, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	60723.78
Authors	Newman, J.A.,Imprachim, N.,Yosaatmadja, Y.,Gileadi, O. (deposition date: 2021-12-14, release date: 2022-02-02, Last modification date: 2024-02-07)
Primary citation	Imprachim, N.,Yosaatmadja, Y.,Newman, J.A. Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development. Nucleic Acids Res., 51:475-487, 2023 Cited by PubMed: 36546776 DOI: 10.1093/nar/gkac1207 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation