5LEJ
 
 | | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a 30-bp operator PrfA-box motif | | 分子名称: | DNA (30-MER), Listeriolysin regulatory protein | | 著者 | Hall, M, Grundstrom, C, Begum, A, Lindberg, M, Sauer, U.H, Almqvist, F, Johansson, J, Sauer-Eriksson, A.E. | | 登録日 | 2016-06-29 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
5J3S
 | | Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor | | 分子名称: | 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, Tyrosyl-DNA phosphodiesterase 2 | | 著者 | Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W. | | 登録日 | 2016-03-31 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473, 2016
|
|
8JTM
 | | CNE55.664 trimer in complex with broadly neutralizing HIV antibody PGT145 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PGT145 antibody fragment, ... | | 著者 | Chatterjee, A, Chen, C, Lee, K, Mangala Prasad, V. | | 登録日 | 2023-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (5.14 Å) | | 主引用文献 | An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting.
Npj Viruses, 1, 2023
|
|
6X94
 | | An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli | | 分子名称: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Zambaldo, C, Koh, M, Nasertorabi, F, Han, G.W, Chatterjee, A, Stevens, R.C, Schultz, P.G. | | 登録日 | 2020-06-02 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.
Bioorg.Med.Chem., 28, 2020
|
|
7PMC
 | | Cryo-EM structure of the actomyosin-V complex in the strong-ADP state (central 1er, class 7) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Pospich, S, Sweeney, H.L, Houdusse, A, Raunser, S. | | 登録日 | 2021-09-02 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.
Elife, 10, 2021
|
|
7NF4
 | |
6UJE
 | | Crystal structure of the Clostridial cellulose synthase subunit Z (CcsZ) from Clostridioides difficile | | 分子名称: | CALCIUM ION, Endoglucanase | | 著者 | Scott, W, Lowrance, B, Anderson, A.C, Weadge, J.T. | | 登録日 | 2019-10-03 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Identification of the Clostridial cellulose synthase and characterization of the cognate glycosyl hydrolase, CcsZ.
Plos One, 15, 2020
|
|
6AWC
 | | Structure of 30S ribosomal subunit and RNA polymerase complex in rotated state | | 分子名称: | 16S rRNA, 30S ribosomal protein S1, 30S ribosomal protein S10, ... | | 著者 | Demo, G, Rasouly, A, Vasilyev, N, Loveland, A.B, Diaz-Avalos, R, Grigorieff, N, Nudler, E, Korostelev, A.A. | | 登録日 | 2017-09-05 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | | 主引用文献 | Structure of RNA polymerase bound to ribosomal 30S subunit.
Elife, 6, 2017
|
|
5IUD
 | |
8GOG
 | | Structure of streptavidin mutant (S112Y-K121E) complexed with biotin-cyclopentadienyl-rhodium (III)(Cp*-Rh(III)) | | 分子名称: | CHLORIDE ION, GLYCEROL, RHODIUM(III) ION, ... | | 著者 | Sairaman, A, Mukherjee, P, Maiti, D, Bhaumik, P. | | 登録日 | 2022-08-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Enantiodivergent synthesis of isoindolones catalysed by a Rh(III)-based artificial metalloenzyme
Nat Synth, 3, 2024
|
|
6XV4
 | | Neutron structure of ferric ascorbate peroxidase-ascorbate complex | | 分子名称: | ASCORBIC ACID, Ascorbate peroxidase, POTASSIUM ION, ... | | 著者 | Kwon, H, Basran, J, Devos, J.M, Schrader, T.E, Ostermann, A, Blakeley, M.P, Raven, E.L, Moody, P.C.E. | | 登録日 | 2020-01-21 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION | | 主引用文献 | Visualizing the protons in a metalloenzyme electron proton transfer pathway.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7PMB
 | | Cryo-EM structure of the actomyosin-V complex in the strong-ADP state (central 1er, class 6) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Pospich, S, Sweeney, H.L, Houdusse, A, Raunser, S. | | 登録日 | 2021-09-02 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.
Elife, 10, 2021
|
|
7SCN
 | |
8DTY
 | |
8DVV
 | | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions | | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | | 著者 | Iyer, K.A, Hu, Y, Murayama, T, Samso, M. | | 登録日 | 2022-07-29 | | 公開日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions
To Be Published
|
|
6XX0
 | | Crystal structure of NEMO in complex with Ubv-LIN | | 分子名称: | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b, ... | | 著者 | Akutsu, M, Skenderovic, A, Garcia-Pardo, J, Maculins, T, Dikic, I. | | 登録日 | 2020-01-26 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
|
|
6XYW
 | | Structure of the plant mitochondrial ribosome | | 分子名称: | 28S ribosomal S34 protein, 3-hydroxyisobutyryl-CoA hydrolase-like protein 2, mitochondrial, ... | | 著者 | Soufari, H, Waltz, F, Bochler, A, Giege, P, Hashem, Y. | | 登録日 | 2020-01-31 | | 公開日 | 2020-04-15 | | 最終更新日 | 2020-04-29 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Cryo-EM structure of the RNA-rich plant mitochondrial ribosome.
Nat.Plants, 6, 2020
|
|
8DTZ
 | |
7NLD
 | | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor | | 分子名称: | N-(2-((2'-chloro-3'-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-methoxy-[1,1'-biphenyl]-4-yl)(methyl)amino)ethyl)methanesulfonamide, Programmed cell death 1 ligand 1 | | 著者 | Sala, D, Magiera-Mularz, K, Muszak, D, Surmiak, E, Grudnik, P, Holak, T.A. | | 登録日 | 2021-02-22 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
J.Med.Chem., 64, 2021
|
|
7APG
 | | Crystal structure of JAK3 in complex with FM587 (compound 9a) | | 分子名称: | 1,2-ETHANEDIOL, 1-phenylurea, Tyrosine-protein kinase JAK3, ... | | 著者 | Chaikuad, A, Forster, M, Gehringer, M, Laufer, S, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-10-16 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.
Int J Mol Sci, 21, 2020
|
|
6UKY
 | | STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 12 | | 分子名称: | 4-(6-{3-[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-4-yl]propyl}-5-methoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | | 著者 | Lesburg, C.A. | | 登録日 | 2019-10-06 | | 公開日 | 2020-08-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity.
Science, 369, 2020
|
|
5LK2
 | |
7PEN
 | |
8T5F
 | | De novo design of high-affinity protein binders to bioactive helical peptides | | 分子名称: | Parathyroid hormone | | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | | 登録日 | 2023-06-13 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
|
|
7PFR
 | |
