8T5F

De novo design of high-affinity protein binders to bioactive helical peptides

Summary for 8T5F

Entry DOI	10.2210/pdb8t5f/pdb
Descriptor	Parathyroid hormone (2 entities in total)
Functional Keywords	alpha-helical peptides, protein design, diffusion, deep learning, de novo protein
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	12377.33
Authors	Torres, S.V.,Leung, P.J.Y.,Bera, A.K.,Baker, D.,Kang, A. (deposition date: 2023-06-13, release date: 2024-01-10, Last modification date: 2024-02-14)
Primary citation	Vazquez Torres, S.,Leung, P.J.Y.,Venkatesh, P.,Lutz, I.D.,Hink, F.,Huynh, H.H.,Becker, J.,Yeh, A.H.,Juergens, D.,Bennett, N.R.,Hoofnagle, A.N.,Huang, E.,MacCoss, M.J.,Exposit, M.,Lee, G.R.,Bera, A.K.,Kang, A.,De La Cruz, J.,Levine, P.M.,Li, X.,Lamb, M.,Gerben, S.R.,Murray, A.,Heine, P.,Korkmaz, E.N.,Nivala, J.,Stewart, L.,Watson, J.L.,Rogers, J.M.,Baker, D. De novo design of high-affinity binders of bioactive helical peptides. Nature, 626:435-442, 2024 Cited by PubMed: 38109936 DOI: 10.1038/s41586-023-06953-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation