8T5F
De novo design of high-affinity protein binders to bioactive helical peptides
Summary for 8T5F
Entry DOI | 10.2210/pdb8t5f/pdb |
Descriptor | Parathyroid hormone (2 entities in total) |
Functional Keywords | alpha-helical peptides, protein design, diffusion, deep learning, de novo protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 12377.33 |
Authors | Torres, S.V.,Leung, P.J.Y.,Bera, A.K.,Baker, D.,Kang, A. (deposition date: 2023-06-13, release date: 2024-01-10, Last modification date: 2024-02-14) |
Primary citation | Vazquez Torres, S.,Leung, P.J.Y.,Venkatesh, P.,Lutz, I.D.,Hink, F.,Huynh, H.H.,Becker, J.,Yeh, A.H.,Juergens, D.,Bennett, N.R.,Hoofnagle, A.N.,Huang, E.,MacCoss, M.J.,Exposit, M.,Lee, G.R.,Bera, A.K.,Kang, A.,De La Cruz, J.,Levine, P.M.,Li, X.,Lamb, M.,Gerben, S.R.,Murray, A.,Heine, P.,Korkmaz, E.N.,Nivala, J.,Stewart, L.,Watson, J.L.,Rogers, J.M.,Baker, D. De novo design of high-affinity binders of bioactive helical peptides. Nature, 626:435-442, 2024 Cited by PubMed: 38109936DOI: 10.1038/s41586-023-06953-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
Download full validation report