7NLD

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

Summary for 7NLD

• Entry DOI: 10.2210/pdb7nld/pdb
• Descriptor: Programmed cell death 1 ligand 1, N-(2-((2'-chloro-3'-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-methoxy-[1,1'-biphenyl]-4-yl)(methyl)amino)ethyl)methanesulfonamide (3 entities in total)
• Functional Keywords: pd-l1, cancer, inhibitor, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 89581.58

Authors

Sala, D.,Magiera-Mularz, K.,Muszak, D.,Surmiak, E.,Grudnik, P.,Holak, T.A. (deposition date: 2021-02-22, release date: 2021-08-11, Last modification date: 2024-01-31)

• Primary citation: Muszak, D.,Surmiak, E.,Plewka, J.,Magiera-Mularz, K.,Kocik-Krol, J.,Musielak, B.,Sala, D.,Kitel, R.,Stec, M.,Weglarczyk, K.,Siedlar, M.,Domling, A.,Skalniak, L.,Holak, T.A.; Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.; J.Med.Chem., 64:11614-11636, 2021; PubMed: 34313116; DOI: 10.1021/acs.jmedchem.1c00957

Experimental method

X-RAY DIFFRACTION (2.3 Å)