4YLJ
 
 | | Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j | | 分子名称: | 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ... | | 著者 | Chaikuad, A, Falke, H, Nowak, R, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Kunick, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2015-03-05 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A.
J.Med.Chem., 58, 2015
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7KOO
 | | Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-bungarotoxin isoform V31, ... | | 著者 | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | | 登録日 | 2020-11-09 | | 公開日 | 2021-03-17 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.
Cell, 184, 2021
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6SFH
 | | CRYSTAL STRUCTURE OF DHQ1 FROM Staphylococcus aureus COVALENTLY MODIFIED BY LIGAND 7 | | 分子名称: | (1~{S},3~{S},4~{S},5~{R})-3-(aminomethyl)-3,4,5-tris(hydroxyl)cyclohexane-1-carboxylic acid, 3-dehydroquinate dehydratase, LITHIUM ION, ... | | 著者 | Sanz-Gaitero, M, Lence, E, Maneiro, M, Thompson, R, Hawkins, A.R, Gonzalez-Bello, C, van Raaij, M.J. | | 登録日 | 2019-08-01 | | 公開日 | 2020-04-15 | | 最終更新日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product.
Chemistry, 26, 2020
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6CLL
 | | 1.02 A MicroED structure of GSNQNNF at 1.2 e- / A^2 | | 分子名称: | ACETATE ION, GSNQNNF, ZINC ION | | 著者 | Hattne, J, Shi, D, Glynn, C, Zee, C.-T, Gallagher-Jones, M, Martynowycz, M.W, Rodriguez, J.A, Gonen, T. | | 登録日 | 2018-03-02 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.02 Å) | | 主引用文献 | Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.
Structure, 26, 2018
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7BSN
 | | Mevo lectin complex with 3alpha-mannobiose | | 分子名称: | alpha-D-mannopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose, lectin | | 著者 | Sivaji, N, Suguna, K, Surolia, A, Vijayan, M. | | 登録日 | 2020-03-31 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and related studies on Mevo lectin from Methanococcus voltae A3: the first thorough characterization of an archeal lectin and its interactions.
Glycobiology, 31, 2021
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6CLT
 | | 1.45 A MicroED structure of GSNQNNF at 3.8 e- / A^2 | | 分子名称: | ACETATE ION, GSNQNNF, ZINC ION | | 著者 | Hattne, J, Shi, D, Glynn, C, Zee, C.-T, Gallagher-Jones, M, Martynowycz, M.W, Rodriguez, J.A, Gonen, T. | | 登録日 | 2018-03-02 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.45 Å) | | 主引用文献 | Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.
Structure, 26, 2018
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5K1A
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6SE3
 | | Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 3-6 | | 分子名称: | Ancestral Flavin-containing monooxygenase (FMO) 3-6, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Nicoll, C, Bailleul, G, Fiorentini, F, Mascotti, M.L, Fraaije, M, Mattevi, A. | | 登録日 | 2019-07-29 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.
Nat.Struct.Mol.Biol., 27, 2020
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3GSU
 | | Crystal structure of the binary complex between HLA-A2 and HCMV NLV-M5T peptide variant | | 分子名称: | Beta-2-microglobulin, HCMV pp65 fragment 495-503, variant M5T (NLVPTVATV), ... | | 著者 | Reiser, J.-B, Saulquin, X, Gras, S, Debeaupuis, E, Echasserieau, K, Kissenpfennig, A, Legoux, F, Chouquet, A, Le Gorrec, M, Machillot, P, Neveu, B, Thielens, N, Malissen, B, Bonneville, M, Housset, D. | | 登録日 | 2009-03-27 | | 公開日 | 2009-08-04 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.
J.Immunol., 183, 2009
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7L25
 | | HPK1 IN COMPLEX WITH COMPOUND 18 | | 分子名称: | 1,2-ETHANEDIOL, 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine, Mitogen-activated protein kinase kinase kinase kinase 1 | | 著者 | Lesburg, C.A. | | 登録日 | 2020-12-16 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Identification of Potent Reverse Indazole Inhibitors for HPK1.
Acs Med.Chem.Lett., 12, 2021
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4Q4J
 | | Structure of crosslinked TM287/288_S498C_S520C mutant | | 分子名称: | ABC transporter, Uncharacterized ABC transporter ATP-binding protein TM_0288 | | 著者 | Hohl, M, Schoeppe, J, Gruetter, M.G, Seeger, M.A. | | 登録日 | 2014-04-14 | | 公開日 | 2014-07-16 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4QEU
 | | Crystal structure of BRD2(BD2) mutant in free form | | 分子名称: | ACETATE ION, Bromodomain-containing protein 2, GLYCEROL | | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | | 登録日 | 2014-05-19 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.
Science, 346, 2014
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3GSN
 | | Crystal structure of the public RA14 TCR in complex with the HCMV dominant NLV/HLA-A2 epitope | | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, HCMV pp65 fragment 495-503 (NLVPMVATV), ... | | 著者 | Gras, S, Saulquin, X, Reiser, J.-B, Debeaupuis, E, Echasserieau, K, Kissenpfennig, A, Legoux, F, Chouquet, A, Le Gorrec, M, Machillot, P, Neveu, B, Thielens, N, Malissen, B, Bonneville, M, Housset, D. | | 登録日 | 2009-03-27 | | 公開日 | 2009-08-04 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.
J.Immunol., 183, 2009
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5TXV
 | | HslU P21 cell with 4 hexamers | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU | | 著者 | Grant, R.A, Chen, J, Glynn, S.E, Sauer, R.T. | | 登録日 | 2016-11-17 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (7.086 Å) | | 主引用文献 | Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation.
J. Biol. Chem., 292, 2017
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4QF4
 | | Crystal structure of Staphylococcal nuclease variant V23M at cryogenic temperature | | 分子名称: | CALCIUM ION, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ... | | 著者 | Caro, J.A, Schlessman, J.L, Heroux, A, Garcia-Moreno, E.B. | | 登録日 | 2014-05-19 | | 公開日 | 2014-06-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Pressure effects in proteins
To be Published
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5CFP
 | | Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]' | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Stimulator of Interferon Genes | | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | | 登録日 | 2015-07-08 | | 公開日 | 2015-08-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.066 Å) | | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
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5CI3
 | | Ribonucleotide reductase Y122 2,3,5-F3Y variant | | 分子名称: | MU-OXO-DIIRON, Ribonucleoside-diphosphate reductase 1 subunit beta, SULFATE ION | | 著者 | Funk, M.A, Drennan, C.L. | | 登録日 | 2015-07-10 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.
J.Am.Chem.Soc., 138, 2016
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4PWN
 | | Crystal structure of Active WNK1 kinase | | 分子名称: | PHOSPHATE ION, Serine/threonine-protein kinase WNK1 | | 著者 | Piala, A, Moon, T, Akella, T, He, H, Cobbm, M.H, Goldsmith, E. | | 登録日 | 2014-03-20 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation.
Sci.Signal., 7, 2014
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4Y3S
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4YQF
 | | GTPase domain of Human Septin 9 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Septin-9 | | 著者 | Matos, S.O, Leonardo, D.A, Macedo, J.N, Pereira, H.M, Araujo, A.P.U, Garratt, R.C. | | 登録日 | 2015-03-13 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | GTPase domain of Human Septin 9
To Be Published
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4Y47
 | | Endothiapepsin in complex with fragment 162 | | 分子名称: | 4-oxo-N-[(1S)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl)butanamide, ACETATE ION, Endothiapepsin, ... | | 著者 | Krimmer, S.G, Krug, M, Uehlein, M, Heine, A, Klebe, G. | | 登録日 | 2015-02-10 | | 公開日 | 2016-02-17 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Crystallographic Fragment Screening of an Entire Library
To Be Published
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7BFS
 | | deoxyxylose nucleic acid hairpin | | 分子名称: | DNA (5'-D(*AP*GP*CP*AP*AP*TP*CP*CP*(XC)P*(XC)P*(XC)P*(XC)P*GP*GP*AP*TP*TP*GP*CP*T)-3') | | 著者 | Mattelaer, C.-A, Mohitosh, M, Smets, L, Maiti, M, Schepers, G, Mattelaer, H.-P, Rosemeyer, H, Herdewijn, P, Lescrinier, E. | | 登録日 | 2021-01-04 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids.
Chembiochem, 22, 2021
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4YQV
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5CMC
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5U40
 | | Human PPARdelta ligand-binding domain in complexed with specific agonist 15 | | 分子名称: | 6-[2-({benzyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, DI(HYDROXYETHYL)ETHER, Peroxisome proliferator-activated receptor delta, ... | | 著者 | Wu, C.-C, Baiga, T.J, Downes, M, La Clair, J.J, Atkins, A.R, Richard, S.B, Stockley-Noel, T.A, Bowman, M.E, Evans, R.M, Noel, J.P. | | 登録日 | 2016-12-03 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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