4QEU

Crystal structure of BRD2(BD2) mutant in free form

Summary for 4QEU

• Entry DOI: 10.2210/pdb4qeu/pdb
• Related: 4QEO 4QEP
• Descriptor: Bromodomain-containing protein 2, ACETATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: bromodomain-containing protein 2, kiaa9001, ring3, transcription regulation, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P25440
• Total number of polymer chains: 1
• Total formula weight: 13484.47

Authors

Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (deposition date: 2014-05-19, release date: 2014-10-29, Last modification date: 2023-09-20)

• Primary citation: Baud, M.G.,Lin-Shiao, E.,Cardote, T.,Tallant, C.,Pschibul, A.,Chan, K.H.,Zengerle, M.,Garcia, J.R.,Kwan, T.T.,Ferguson, F.M.,Ciulli, A.; Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.; Science, 346:638-641, 2014; PubMed: 25323695; DOI: 10.1126/science.1249830

Experimental method

X-RAY DIFFRACTION (1.5 Å)