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3GSN

Crystal structure of the public RA14 TCR in complex with the HCMV dominant NLV/HLA-A2 epitope

Summary for 3GSN
Entry DOI10.2210/pdb3gsn/pdb
Related3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, HCMV pp65 fragment 495-503 (NLVPMVATV), Beta-2-microglobulin, ... (8 entities in total)
Functional Keywordshla, human cytomegalovirus, pp65, t cell receptor (tcr), immune response, public response, immunodominance, restrained response, host-virus interaction, membrane, mhc i, polymorphism, immunoglobulin domain, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted: P61769
Total number of polymer chains5
Total formula weight94095.79
Authors
Primary citationGras, S.,Saulquin, X.,Reiser, J.B.,Debeaupuis, E.,Echasserieau, K.,Kissenpfennig, A.,Legoux, F.,Chouquet, A.,Le Gorrec, M.,Machillot, P.,Neveu, B.,Thielens, N.,Malissen, B.,Bonneville, M.,Housset, D.
Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.
J.Immunol., 183:430-437, 2009
Cited by
PubMed: 19542454
DOI: 10.4049/jimmunol.0900556
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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