3GSN
Crystal structure of the public RA14 TCR in complex with the HCMV dominant NLV/HLA-A2 epitope
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 274 | 31753.1 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (P) | HCMV pp65 fragment 495-503 (NLVPMVATV) | polymer | 9 | 943.2 | 1 | |||
| 3 | C (L) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 4 | D (A) | RA14 TCR alpha chain (TRAV24, TRAJ49) | polymer | 199 | 22266.4 | 1 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 5 | E (B) | RA14 TCR beta chain (TRBV6-5, TRBD1, TRBJ1-2) | polymer | 243 | 27122.2 | 1 | Homo sapiens (human) | ||
| 6 | F (L) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | H, I, J, K (H, L, A, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
H: 1 - 274 (UniProt: P01892)
L: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Val 245 | Ala 269 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93964.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 131.5 | |
| All* | Total formula weight | 94095.8 |
