7L25

HPK1 IN COMPLEX WITH COMPOUND 18

Summary for 7L25

• Entry DOI: 10.2210/pdb7l25/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 65950.85

Authors

Lesburg, C.A. (deposition date: 2020-12-16, release date: 2021-03-17, Last modification date: 2024-04-03)

• Primary citation: Yu, E.C.,Methot, J.L.,Fradera, X.,Lesburg, C.A.,Lacey, B.M.,Siliphaivanh, P.,Liu, P.,Smith, D.M.,Xu, Z.,Piesvaux, J.A.,Kawamura, S.,Xu, H.,Miller, J.R.,Bittinger, M.,Pasternak, A.; Identification of Potent Reverse Indazole Inhibitors for HPK1.; Acs Med.Chem.Lett., 12:459-466, 2021; PubMed: 33738073; DOI: 10.1021/acsmedchemlett.0c00672

Experimental method

X-RAY DIFFRACTION (1.85 Å)