7L25
HPK1 IN COMPLEX WITH COMPOUND 18
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 289 | 32432.8 | 2 | UniProt (Q92918) Pfam (PF00069) In PDB | Homo sapiens | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEKKK 1 |
| 2 | A, B | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine | non-polymer | 418.5 | 2 | Chemie (XHS) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 294 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Ala 171 | Ser 171 | engineered mutation |
| Cys 191 | Gly 191 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64865.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1085.2 | |
| All* | Total formula weight | 65950.9 |
