4UMW
| CRYSTAL STRUCTURE OF A ZINC-TRANSPORTING PIB-TYPE ATPASE IN E2.PI STATE | Descriptor: | MAGNESIUM ION, TETRAFLUOROALUMINATE ION, ZINC-TRANSPORTING ATPASE | Authors: | Wang, K.T, Sitsel, O, Meloni, G, Autzen, H.E, Andersson, M, Klymchuk, T, Nielsen, A.M, Rees, D.C, Nissen, P, Gourdon, P. | Deposit date: | 2014-05-21 | Release date: | 2014-08-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases. Nature, 514, 2014
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4UNF
| Crystal structure of Deinococcus radiodurans Endonuclease III-1 | Descriptor: | ACETATE ION, ENDONUCLEASE III-1, IRON/SULFUR CLUSTER, ... | Authors: | Sarre, A, Okvist, M, Klar, T, Hall, D, Smalas, A.O, McSweeney, S, Timmins, J, Moe, E. | Deposit date: | 2014-05-28 | Release date: | 2015-06-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural and Functional Characterization of Two Unusual Endonuclease III Enzymes from Deinococcus Radiodurans. J.Struct.Biol., 191, 2015
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8THV
| FARFAR-NMR ensemble of HIV-1 TAR with apical loop capturing ground and excited conformational states | Descriptor: | RNA (29-MER) | Authors: | Roy, R, Geng, A, Shi, H, Merriman, D.K, Dethoff, E.A, Salmon, L, Al-Hashimi, H.M. | Deposit date: | 2023-07-18 | Release date: | 2023-08-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Kinetic Resolution of the Atomic 3D Structures Formed by Ground and Excited Conformational States in an RNA Dynamic Ensemble. J.Am.Chem.Soc., 145, 2023
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5JUT
| Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-05-10 | Release date: | 2016-10-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife, 5, 2016
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8PIP
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4V5H
| E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide. | Descriptor: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Seidelt, B, Innis, C.A, Wilson, D.N, Gartmann, M, Armache, J, Villa, E, Trabuco, L.G, Becker, T, Mielke, T, Schulten, K, Steitz, T.A, Beckmann, R. | Deposit date: | 2009-10-26 | Release date: | 2014-07-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structural insight into nascent polypeptide chain-mediated translational stalling. Science, 326, 2009
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6OCQ
| Crystal structure of RIP1 kinase in complex with a pyrrolidine | Descriptor: | 1-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one, Receptor-interacting serine/threonine-protein kinase 1, SULFATE ION | Authors: | Thorpe, J.H, Harris, P.A. | Deposit date: | 2019-03-25 | Release date: | 2019-05-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.793 Å) | Cite: | Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
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4V4G
| Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y. | Descriptor: | 16S ribosomal RNA, 23S RIBOSOMAL RNA, 30S ribosomal protein S10, ... | Authors: | Vila-Sanjurjo, A, Schuwirth, B.S, Hau, C.W, Cate, J.H. | Deposit date: | 2004-10-06 | Release date: | 2014-07-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (11.5 Å) | Cite: | Structural basis for the control of translation initiation during stress. Nat.Struct.Mol.Biol., 11, 2004
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8TP6
| H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 4-1-1E02 Fab, ... | Authors: | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | Deposit date: | 2023-08-04 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination. Biorxiv, 2023
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8U3M
| The FARFAR-MD-NMR ensemble of an HIV-1 TAR excited state | Descriptor: | The excited state of HIV-1 transactivation response element (31-MER) | Authors: | Geng, A, Ganser, L, Roy, R, Shi, H, Pratihar, S, Case, D.A, Al-Hashimi, H.M. | Deposit date: | 2023-09-07 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | An RNA excited conformational state at atomic resolution. Nat Commun, 14, 2023
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8U7Z
| KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(CTD)/Gbeta1gamma2 | Descriptor: | BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TP7
| H2 hemagglutinin (A/Singapore/1/1957) in complex with Sa-targeting Fab 4-1-1G03 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of monoclonal antibody 4-1-1G03, ... | Authors: | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | Deposit date: | 2023-08-04 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination. Biorxiv, 2023
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8U81
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U82
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U83
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.975 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TP2
| H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting 1-1-1F05 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 1-1-1F05, ... | Authors: | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | Deposit date: | 2023-08-04 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination. Biorxiv, 2023
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8U84
| KCTD5/Cullin3/Gbeta1gamma2 Complex: State D From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U80
| KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD) | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3 | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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6OR8
| An Unexpected Intermediate in the Reaction Catalyzed by Quinolinate Synthase | Descriptor: | 2-hydroxy-N-[(1S)-1-hydroxy-3-oxopropyl]-L-aspartic acid, IRON/SULFUR CLUSTER, PHOSPHATE ION, ... | Authors: | Esakova, O.A, Grove, T.L, Yennawar, N.H, Booker, S.J. | Deposit date: | 2019-04-29 | Release date: | 2019-10-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase. J.Am.Chem.Soc., 141, 2019
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8TSA
| Human PI3K p85alpha/p110alpha H1047R bound to compound 2 | Descriptor: | 5-(3-bromo-5-fluorobenzamido)-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J, Valverde, R. | Deposit date: | 2023-08-11 | Release date: | 2023-11-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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8TSB
| Human PI3K p85alpha/p110alpha bound to compound 2 | Descriptor: | 5-(3-bromo-5-fluorobenzamido)-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J. | Deposit date: | 2023-08-11 | Release date: | 2023-11-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.53 Å) | Cite: | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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6U8K
| Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3 | Descriptor: | Heavy chain of Fab HCV3, JIIIabc RNA (68-MER), Light chain of Fab HCV3 | Authors: | Koirala, D, Lewicka, A, Koldobskaya, Y, Huang, H, Piccirilli, J.A. | Deposit date: | 2019-09-05 | Release date: | 2019-12-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. Acs Chem.Biol., 15, 2020
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8TS8
| p85alpha/p110alpha heterodimer H1047R mutant | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J. | Deposit date: | 2023-08-11 | Release date: | 2023-11-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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8TS7
| Human PI3K p85alpha/p110alpha | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J. | Deposit date: | 2023-08-11 | Release date: | 2023-11-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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8TSD
| Human PI3K p85alpha/p110alpha bound to RLY-2608 | Descriptor: | N-{(3R,6M)-3-(2-chloro-5-fluorophenyl)-6-[(4S)-5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-3-fluoro-5-(trifluoromethyl)benzamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J. | Deposit date: | 2023-08-11 | Release date: | 2023-11-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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