Search by PDB author

Multidrug resistance-associated protein 3
分子名称:	ATP-binding cassette sub-family C member 3
著者	Yun, C.H, Gao, H.M.
登録日	2023-04-07
公開日	2024-04-10
実験手法	ELECTRON MICROSCOPY (3.31 Å)
主引用文献	structure of multidrug resistance-associated protein 3 at 3.31 Angstroms To Be Published

8IZR

Multidrug resistance-associated protein 3
分子名称:	ATP-binding cassette sub-family C member 2
著者	Yun, C.H, Gao, H.M.
登録日	2023-04-07
公開日	2024-04-10
実験手法	ELECTRON MICROSCOPY (3.62 Å)
主引用文献	structure of multidrug resistance-associated protein 2 at 3.62 Angstroms resolution To Be Published

7BTT

A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain
分子名称:	2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5H-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone, ALK tyrosine kinase receptor
著者	Yun, C.H, Zhu, S.J.
登録日	2020-04-02
公開日	2021-04-07
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain To Be Published

4WD5

Crystal structure of EGFR 696-1022 T790M in complex with QL-X138
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N-{2-methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl]phenyl}propanamide
著者	Yun, C.H, Eck, M.J.
登録日	2014-09-07
公開日	2016-05-04
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Crystal structure of EGFR 696-1022 T790M in complex with QL-X138 To Be Published

1TGR

Crystal Structure of mini-IGF-1(2)
分子名称:	Insulin-like growth factor IA
著者	Liang, D.C, Yun, C.H, Chang, W.R.
登録日	2004-05-29
公開日	2004-12-28
最終更新日	2021-11-10
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	1.42A crystal structure of mini-IGF-1(2): an analysis of the disulfide isomerization property and receptor binding property of IGF-1 based on the three-dimensional structure Biochem.Biophys.Res.Commun., 326, 2004

4LRM

EGFR D770_N771insNPG in complex with PD168393
分子名称:	Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide
著者	Yun, C.H, Eck, M.J.
登録日	2013-07-20
公開日	2014-01-15
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (3.526 Å)
主引用文献	Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer. Sci Transl Med, 5, 2013

4LL0

EGFR L858R/T790M in complex with PD168393
分子名称:	Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide
著者	Yun, C.H, Eck, M.J.
登録日	2013-07-09
公開日	2013-09-11
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (4 Å)
主引用文献	Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proc.Natl.Acad.Sci.USA, 110, 2013

5CZH

EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE
分子名称:	Epidermal growth factor receptor, Peptide substrate
著者	Yun, C.H, Eck, M.J.
登録日	2015-07-31
公開日	2015-09-30
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat.Struct.Mol.Biol., 22, 2015

5CZI

EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE
分子名称:	Epidermal growth factor receptor, SHC Peptide substrate
著者	Yun, C.H, Eck, M.J.
登録日	2015-07-31
公開日	2015-09-30
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat.Struct.Mol.Biol., 22, 2015

6P8Q

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.
分子名称:	1,2-ETHANEDIOL, 10-benzyl-2-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, ADENOSINE MONOPHOSPHATE, ...
著者	Yun, C.H, Heppner, D.E, Eck, M.J.
登録日	2019-06-07
公開日	2019-12-18
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Med.Chem.Lett., 10, 2019

5X2A

Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(3)
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, Epidermal growth factor receptor, ...
著者	Yun, C.H.
登録日	2017-01-31
公開日	2018-02-07
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9, 2018

5X28

Crystal structure of EGFR 696-1022 L858R in complex with SKLB(6)
分子名称:	9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, CHLORIDE ION, Epidermal growth factor receptor
著者	Yun, C.H.
登録日	2017-01-31
公開日	2018-02-07
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.952 Å)
主引用文献	Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9, 2018

5X2C

Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(5)
分子名称:	1,2-ETHANEDIOL, 9-cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, CHLORIDE ION, ...
著者	Yun, C.H.
登録日	2017-01-31
公開日	2018-02-21
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9, 2018

5X2F

Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)
分子名称:	9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, Epidermal growth factor receptor
著者	Yun, C.H.
登録日	2017-01-31
公開日	2018-02-07
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9, 2018

5X27

Crystal structure of EGFR 696-1022 L858R in complex with SKLB(5)
分子名称:	9-cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, CHLORIDE ION, Epidermal growth factor receptor
著者	Yun, C.H.
登録日	2017-01-31
公開日	2018-02-07
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.952 Å)
主引用文献	Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9, 2018

5X26

Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-9-propan-2-yl-purine-2,8-diamine
著者	Yun, C.H.
登録日	2017-01-31
公開日	2018-02-07
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.951 Å)
主引用文献	Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9, 2018

1RFJ

Crystal Structure of Potato Calmodulin PCM6
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, calmodulin
著者	Liang, D.C, Yun, C.H, Chang, W.R.
登録日	2003-11-10
公開日	2004-06-29
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structure of potato calmodulin PCM6: the first report of the three-dimensional structure of a plant calmodulin. Acta Crystallogr.,Sect.D, 60, 2004

5J87

Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
分子名称:	N-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide, Tyrosine-protein kinase BTK
著者	Yun, C.H, Zhang, S.
登録日	2016-04-07
公開日	2017-04-19
最終更新日	2017-10-04
実験手法	X-RAY DIFFRACTION (1.59 Å)
主引用文献	Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem, 131, 2017

4LQM

EGFR L858R in complex with PD168393
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
著者	Yun, C.H, Eck, M.J.
登録日	2013-07-19
公開日	2014-01-15
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer. Sci Transl Med, 5, 2013

6JXT

Crystal structure of EGFR 696-1022 WT in complex with AZD9291 prepared by cocrystallization
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Yun, C.H, Zhu, S.J, Yan, X.E.
登録日	2019-04-25
公開日	2020-04-29
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.307 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

6JX0

Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by co-crystallization
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Yun, C.H, Yan, X.E, Zhu, S.J.
登録日	2019-04-21
公開日	2020-04-22
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.53 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

6JWL

Crystal structure of EGFR 696-1022 L858R in complex with AZD9291
分子名称:	Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Yun, C.H, Zhu, S.J, Yan, X.E.
登録日	2019-04-21
公開日	2020-04-22
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.551 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

5K5X

Crystal structure of human PDGFRA
分子名称:	Platelet-derived growth factor receptor alpha, SULFATE ION
著者	Yan, X.E, Liang, L, Yun, C.H.
登録日	2016-05-24
公開日	2016-08-17
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.168 Å)
主引用文献	Structural and biochemical studies of the PDGFRA kinase domain Biochem.Biophys.Res.Commun., 477, 2016

8H75

FGFR2 in complex with YJ001
分子名称:	CHLORIDE ION, Fibroblast growth factor receptor 2, Tinengotinib
著者	Yan, X.E, Yun, C.H.
登録日	2022-10-19
公開日	2023-10-25
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (3.75 Å)
主引用文献	FGFR2 in complex with YJ001 To Be Published

4YL9

Crystal Structure of wild-type of hsp14.1 from Sulfolobus solfatataricus P2
分子名称:	1,2-ETHANEDIOL, CALCIUM ION, Heat shock protein Hsp20
著者	Liu, L, Chen, J.Y, Yun, C.H.
登録日	2015-03-05
公開日	2015-11-04
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.353 Å)
主引用文献	Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function Structure, 23, 2015

12 3 4 5 >

全ヒット件数:	120
表示件数:	25
表示順	関連性が高い順