6JX0

Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by co-crystallization

Summary for 6JX0

• Entry DOI: 10.2210/pdb6jx0/pdb
• Related: 6JWL
• Descriptor: Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: complex, inhibitor, egfr., oncoprotein, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39255.78

Authors

Yun, C.H.,Yan, X.E.,Zhu, S.J. (deposition date: 2019-04-21, release date: 2020-04-22, Last modification date: 2020-11-04)

• Primary citation: Yan, X.E.,Ayaz, P.,Zhu, S.J.,Zhao, P.,Liang, L.,Zhang, C.H.,Wu, Y.C.,Li, J.L.,Choi, H.G.,Huang, X.,Shan, Y.,Shaw, D.E.,Yun, C.H.; Structural Basis of AZD9291 Selectivity for EGFR T790M.; J.Med.Chem., 63:8502-8511, 2020; PubMed: 32672461; DOI: 10.1021/acs.jmedchem.0c00891

Experimental method

X-RAY DIFFRACTION (2.53 Å)