4WD5

Crystal structure of EGFR 696-1022 T790M in complex with QL-X138

Summary for 4WD5

• Entry DOI: 10.2210/pdb4wd5/pdb
• Descriptor: Epidermal growth factor receptor, N-{2-methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl]phenyl}propanamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: egfr, t790m, gatekeeper mutation, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 2
• Total formula weight: 75784.01

Authors

Yun, C.H.,Eck, M.J. (deposition date: 2014-09-07, release date: 2016-05-04, Last modification date: 2024-10-23)

• Primary citation: Wu, H.,Hu, C.,Wang, A.,Weisberg, E.E.,Chen, Y.,Yun, C.H.,Wang, W.,Liu, X.,Tian, B.,Wang, J.,Zhao, Z.,Liang, Y.,Li, B.,Wang, L.,Wang, B.,Chen, C.,Buhrlage, S.J.,Fernadners, S.M.,Griffin, J.,Brown, J.R.,Eck, M.J.,Liu, J.,Liu, Q.,Gray, N.S.; Crystal structure of EGFR 696-1022 T790M in complex with QL-X138; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.3 Å)