4WD5
Crystal structure of EGFR 696-1022 T790M in complex with QL-X138
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epidermal growth factor receptor | polymer | 331 | 37662.5 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | N-{2-methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl]phenyl}propanamide | non-polymer | 423.5 | 1 | Chemie (3LH) | |||
| 3 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B: 694 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75325.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 458.9 | |
| All* | Total formula weight | 75784.0 |
