8YTN
| Single-chain Fv antibody of E11 | 分子名称: | GLYCEROL, Single-chain Fv antibody of E11 | 著者 | Yoshida, M, Hanazono, Y, Numoto, N, Ito, N, Oda, M. | 登録日 | 2024-03-26 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Affinity-matured antibody with a disulfide bond in H-CDR3 loop. Arch.Biochem.Biophys., 758, 2024
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8YTP
| Single-chain Fv antibody of E11 complex with NP-glycine under reducing conditions | 分子名称: | 2-[2-(3-nitro-4-oxidanyl-phenyl)ethanoylamino]ethanoic acid, Single-chain Fv antibody of E11 | 著者 | Yoshida, M, Hanazono, Y, Numoto, N, Ito, N, Oda, M. | 登録日 | 2024-03-26 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Affinity-matured antibody with a disulfide bond in H-CDR3 loop. Arch.Biochem.Biophys., 758, 2024
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8YTO
| Single-chain Fv antibody of E11 complex with NP-glycine | 分子名称: | 2-[2-(3-nitro-4-oxidanyl-phenyl)ethanoylamino]ethanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | 著者 | Yoshida, M, Hanazono, Y, Numoto, N, Ito, N, Oda, M. | 登録日 | 2024-03-26 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Affinity-matured antibody with a disulfide bond in H-CDR3 loop. Arch.Biochem.Biophys., 758, 2024
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7W5O
| Crystal structure of ERK2 with an allosteric inhibitor | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 13-[4-({Imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-4,8-dioxa-12,14,16,18-tetraazatetracyclo[9.7.0.0^{3,9}.0^{12,17}]octadeca-1(11),2,9,15,17-pentaen-15-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Yoshida, M, Kinoshita, T. | 登録日 | 2021-11-30 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Identification of a novel target site for ATP-independent ERK2 inhibitors. Biochem.Biophys.Res.Commun., 593, 2022
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7XC1
| Crystal structure of ERK2 with an allosteric inhibitor 3 | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | 著者 | Yoshida, M, Kinoshita, T. | 登録日 | 2022-03-22 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural basis for ERK2 allosteric inhibitors. To Be Published
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7X4U
| Crystal structure of ERK2 with an allosteric inhibitor 2 | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | 著者 | Yoshida, M, Kinoshita, T. | 登録日 | 2022-03-03 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural basis for producing allosteric ERK2 inhibitors To Be Published
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4V4O
| Crystal Structure of the Chaperonin Complex Cpn60/Cpn10/(ADP)7 from Thermus Thermophilus | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | 著者 | Shimamura, T, Koike-Takeshita, A, Yokoyama, K, Masui, R, Murai, N, Yoshida, M, Taguchi, H, Iwata, S. | 登録日 | 2004-05-23 | 公開日 | 2014-07-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity STRUCTURE, 12, 2004
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1QVR
| Crystal Structure Analysis of ClpB | 分子名称: | ClpB protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLATINUM (II) ION | 著者 | Lee, S, Sowa, M.E, Watanabe, Y, Sigler, P.B, Chiu, W, Yoshida, M, Tsai, F.T.F. | 登録日 | 2003-08-28 | 公開日 | 2003-10-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Structure of ClpB: A Molecular Chaperone that Rescues Proteins from an Aggregated State Cell(Cambridge,Mass.), 115, 2003
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8CAX
| Structure of Tau filaments Type II from Subacute Sclerosing Panencephalitis | 分子名称: | Microtubule-associated protein tau | 著者 | Qi, C, Hasegawa, M, Takao, M, Sakai, M, Akagi, M, Iwasaki, Y, Yoshida, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2023-01-24 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy. Acta Neuropathol Commun, 11, 2023
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8CAQ
| Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis | 分子名称: | Microtubule-associated protein tau | 著者 | Qi, C, Hasegawa, M, Takao, M, Sakai, M, Akagi, M, Iwasaki, Y, Yoshida, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2023-01-24 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy. Acta Neuropathol Commun, 11, 2023
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6XYO
| Multiple system atrophy Type I alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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4XD7
| Structure of thermophilic F1-ATPase inhibited by epsilon subunit | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP synthase epsilon chain, ATP synthase gamma chain, ... | 著者 | SHIRAKIHARA, Y, SHIRATORI, A, TANIKAWA, H, NAKASAKO, M, YOSHIDA, M, SUZUKI, T. | 登録日 | 2014-12-19 | 公開日 | 2015-08-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structure of a thermophilic F1 -ATPase inhibited by an epsilon-subunit: deeper insight into the epsilon-inhibition mechanism. Febs J., 282, 2015
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6XYP
| Multiple system atrophy Type II-1 alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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6XYQ
| Multiple system atrophy Type II-2 alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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4Y6L
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6EII
| The crystal structure of CK2alpha in complex with compound 18 | 分子名称: | (3-chloranyl-4-phenyl-phenyl)methyl-(3-phenylpropyl)azanium, ACETATE ION, Casein kinase II subunit alpha, ... | 著者 | Brear, P, De Fusco, C, Iegre, J, Yoshida, M, Mitchell, S, Rossmann, M, Carro, L, Sore, H, Hyvonen, M, Spring, D. | 登録日 | 2017-09-19 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.935 Å) | 主引用文献 | Second-generation CK2 alpha inhibitors targeting the alpha D pocket. Chem Sci, 9, 2018
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6EHK
| The crystal structure of CK2alpha in complex with CAM4712 and compound 37 | 分子名称: | 2-(1~{H}-benzimidazol-2-yl)-~{N}-[[3,5-bis(chloranyl)-4-(2-ethylphenyl)phenyl]methyl]ethanamine, 2-hydroxy-5-methylbenzoic acid, ACETATE ION, ... | 著者 | Brear, P, De Fusco, C, Iegre, J, Yoshida, M, Mitchell, S, Rossmann, M, Carro, L, Sore, H, Hyvonen, M, Spring, D. | 登録日 | 2017-09-13 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Second-generation CK2 alpha inhibitors targeting the alpha D pocket. Chem Sci, 9, 2018
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6EHU
| The crystal structure of CK2alpha in complex with compound 32 | 分子名称: | 2-(1~{H}-benzimidazol-2-yl)-~{N}-[[4-(2-ethylphenyl)-3-(trifluoromethyl)phenyl]methyl]ethanamine, ACETATE ION, Casein kinase II subunit alpha | 著者 | Brear, P, De Fusco, C, Iegre, J, Yoshida, M, Mitchell, S, Rossmann, M, Carro, L, Sore, H, Hyvonen, M, Spring, D. | 登録日 | 2017-09-15 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Second-generation CK2 alpha inhibitors targeting the alpha D pocket. Chem Sci, 9, 2018
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7P68
| Globular glial tauopathy type 3 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6D
| Argyrophilic grain disease type 1 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P67
| Globular glial tauopathy type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6E
| Argyrophilic grain disease type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6A
| Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P65
| Progressive supranuclear palsy tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P66
| Globular glial tauopathy type 1 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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