5H0V
 
 | | Crystal structure of H88A mutated human transthyretin | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Transthyretin | | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | | 登録日 | 2016-10-07 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
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5H0W
 | | Crystal structure of H88F mutated human transthyretin | | 分子名称: | SULFATE ION, Transthyretin | | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | | 登録日 | 2016-10-07 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
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5H0Y
 | | Crystal structure of H88Y mutated human transthyretin | | 分子名称: | CHLORIDE ION, SULFATE ION, Transthyretin | | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | | 登録日 | 2016-10-07 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
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4PWF
 | | Crystal structure of V30M mutant human transthyretin complexed with ferulic acid phenethyl ester | | 分子名称: | 2-phenylethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-03-20 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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4PWH
 | | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester | | 分子名称: | 3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, CALCIUM ION, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-03-20 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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4PWI
 | | Crystal structure of V30M mutant human transthyretin complexed with rosmarinic acid | | 分子名称: | (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-03-20 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.494 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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4PWE
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4PWJ
 | | Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid | | 分子名称: | 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-03-20 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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4PWG
 | | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester | | 分子名称: | CALCIUM ION, Transthyretin, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-03-20 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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4PWK
 | | Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid | | 分子名称: | 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol), Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-03-20 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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4QRF
 | | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester | | 分子名称: | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | | 登録日 | 2014-06-30 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
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3J0E
 | | Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex | | 分子名称: | 30S ribosomal protein S12, Elongation factor G, Ribosome-recycling factor, ... | | 著者 | Yokoyama, T, Shaikh, T.R, Iwakura, N, Kaji, H, Kaji, A, Agrawal, R.K. | | 登録日 | 2011-06-29 | | 公開日 | 2012-04-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (9.9 Å) | | 主引用文献 | Structural insights into initial and intermediate steps of the ribosome-recycling process.
Embo J., 31, 2012
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3J0D
 | | Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex | | 分子名称: | 30S ribosomal protein S12, 50S ribosomal protein L11, Ribosome-recycling factor, ... | | 著者 | Yokoyama, T, Shaikh, T.R, Iwakura, N, Kaji, H, Kaji, A, Agrawal, R.K. | | 登録日 | 2011-06-29 | | 公開日 | 2012-04-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (11.1 Å) | | 主引用文献 | Structural insights into initial and intermediate steps of the ribosome-recycling process.
Embo J., 31, 2012
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5AYT
 | | Crystal structure of transthyretin in complex with L6 | | 分子名称: | 2-oxidanyl-6-(phenylcarbonyl)benzo[de]isoquinoline-1,3-dione, Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M, Kai, H. | | 登録日 | 2015-09-03 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
J. Pharmacol. Sci., 129, 2015
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8IG1
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6IN0
 | | Crystal structure of EphA3 in complex with 18-Crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, CHLORIDE ION, Ephrin type-A receptor 3 | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
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6IMZ
 | | Crystal structure of MTH1 in complex with 18-Crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ... | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
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6IMX
 | | Crystal structure of V30M mutated transthyretin in complex with 18-Crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors.
J. Med. Chem., 62, 2019
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6IN4
 | | Crystal structure of apo DAPK1 in the presence of 18-crown-6 | | 分子名称: | Death-associated protein kinase 1, SULFATE ION | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
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6IN3
 | | Crystal structure of DOT1L in complex with 18-Crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
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6IN1
 | | Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, ... | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
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6IMY
 | | Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6 | | 分子名称: | 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecine-18-carboxylic acid, Transthyretin | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors.
J. Med. Chem., 62, 2019
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6IN2
 | | Crystal structure of BRD1 in complex with 18-Crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ACETATE ION, Bromodomain-containing protein 1 | | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
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3D6L
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8IE8
 | | Crystal structure of DAPK1 in complex with isorhapontigenin | | 分子名称: | 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, Death-associated protein kinase 1, SULFATE ION | | 著者 | Yokoyama, T. | | 登録日 | 2023-02-15 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1.
Febs J., 290, 2023
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