3JBV
| Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | Authors: | Zhang, J, Pan, X.J, Yan, K.G, Sun, S, Gao, N, Sui, S.F. | Deposit date: | 2015-10-16 | Release date: | 2016-01-27 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Mechanisms of ribosome stalling by SecM at multiple elongation steps Elife, 4, 2015
|
|
6TNT
| SUMOylated apoAPC/C with repositioned APC2 WHB domain | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Barford, D, Yatskevich, S. | Deposit date: | 2019-12-10 | Release date: | 2021-01-13 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation. Cell Rep, 34, 2021
|
|
5UL1
| The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide and a rationally designed PI3K-alpha mutant that mimics ATR | Descriptor: | 3-amino-6-(4-{[(2S)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-N-phenylpyrazine-2-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Knapp, M.S, Elling, R.A, Mamo, M. | Deposit date: | 2017-01-23 | Release date: | 2017-05-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
|
|
5UKJ
| The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR | Descriptor: | N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Knapp, M.S, Elling, R.A, Mamo, M. | Deposit date: | 2017-01-23 | Release date: | 2017-05-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
|
|
5UK8
| The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR | Descriptor: | (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Knapp, M.S, Mamo, M, Elling, R.A. | Deposit date: | 2017-01-20 | Release date: | 2017-06-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
|
|
5ERC
| |
8WH9
| Structure of DDM1-nucleosome complex in ADP-BeFx state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Liu, Y, Zhang, Z, Du, J. | Deposit date: | 2023-09-22 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
|
|
8WH8
| Structure of DDM1-nucleosome complex in ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, DNA (antisense strand), ... | Authors: | Liu, Y, Zhang, Z, Du, J. | Deposit date: | 2023-09-22 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
|
|
8WHB
| Structure of nucleosome core particle of Arabidopsis thaliana | Descriptor: | DNA (antisense strand), DNA (sense strand), Histone H2A.6, ... | Authors: | Liu, Y, Zhang, Z, Du, J. | Deposit date: | 2023-09-23 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
|
|
8WHA
| Structure of DDM1-nucleosome complex in the ADP-BeFx state with DDM1 bound to SHL2 and SHL-2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Liu, Y, Zhang, Z, Du, J. | Deposit date: | 2023-09-22 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
|
|
8WH5
| Structure of DDM1-nucleosome complex in the apo state | Descriptor: | ATP-dependent DNA helicase DDM1, DNA (antisense strand), DNA (sense strand), ... | Authors: | Liu, Y, Zhang, Z, Du, J. | Deposit date: | 2023-09-22 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
|
|
8GQU
| AK-42 inhibitor binding human ClC-2 TMD | Descriptor: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-08-30 | Release date: | 2023-07-05 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 Nat Commun, 14, 2023
|
|
7BV8
| Mature 50S ribosomal subunit from RrmJ knock out E.coli strain | Descriptor: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | Authors: | Wang, W, Li, W.Q, Ge, X.L, Yan, K.G, Mandava, C.S, Sanyal, S, Gao, N. | Deposit date: | 2020-04-09 | Release date: | 2020-07-01 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5GPN
| Architecture of mammalian respirasome | Descriptor: | Acyl carrier protein, COPPER (II) ION, Cytochrome b, ... | Authors: | Gu, J, Wu, M, Guo, R, Yang, M. | Deposit date: | 2016-08-03 | Release date: | 2017-04-05 | Last modified: | 2017-04-12 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | The architecture of the mammalian respirasome. Nature, 537, 2016
|
|
7YV9
| |
7JVO
| |
7EBJ
| Apo structure of the mouse Trim66 PHD-Bromo dual domain | Descriptor: | Tripartite motif-containing protein 66, ZINC ION | Authors: | Wang, Z, Jiang, J. | Deposit date: | 2021-03-09 | Release date: | 2022-03-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell, 29, 2022
|
|
7EBK
| |
7XLB
| |
7XF5
| Full length human CLC-2 channel in apo state | Descriptor: | Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-04-01 | Release date: | 2023-05-03 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 Nat Commun, 14, 2023
|
|
7XJA
| TMD masked refine map of human ClC-2 | Descriptor: | Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-04-15 | Release date: | 2023-05-17 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 Nat Commun, 14, 2023
|
|
7YHP
| |
7YHQ
| |
7YHO
| |