7XF5

Full length human CLC-2 channel in apo state

Summary for 7XF5

• Entry DOI: 10.2210/pdb7xf5/pdb
• EMDB information: 33169
• Descriptor: Chloride channel protein 2 (1 entity in total)
• Functional Keywords: homo-dimer, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 197284.70

Authors

Wang, L. (deposition date: 2022-04-01, release date: 2023-05-03, Last modification date: 2023-11-15)

• Primary citation: Ma, T.,Wang, L.,Chai, A.,Liu, C.,Cui, W.,Yuan, S.,Wing Ngor Au, S.,Sun, L.,Zhang, X.,Zhang, Z.,Lu, J.,Gao, Y.,Wang, P.,Li, Z.,Liang, Y.,Vogel, H.,Wang, Y.T.,Wang, D.,Yan, K.,Zhang, H.; Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42; Nat Commun, 14:3424-, 2023; DOI: 10.1038/s41467-023-39218-6

Experimental method

ELECTRON MICROSCOPY (3.9 Å)