5UKJ
The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR
Summary for 5UKJ
Entry DOI | 10.2210/pdb5ukj/pdb |
Related | 5UK8 5UL1 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | inhibitor, lipid kinase, mutation, atr, transferase-signaling protein-inhibitor complex, transferase/signaling protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 160823.12 |
Authors | Knapp, M.S.,Elling, R.A.,Mamo, M. (deposition date: 2017-01-23, release date: 2017-05-10, Last modification date: 2024-04-03) |
Primary citation | Lu, Y.,Knapp, M.,Crawford, K.,Warne, R.,Elling, R.,Yan, K.,Doyle, M.,Pardee, G.,Zhang, L.,Ma, S.,Mamo, M.,Ornelas, E.,Pan, Y.,Bussiere, D.,Jansen, J.,Zaror, I.,Lai, A.,Barsanti, P.,Sim, J. Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429:1684-1704, 2017 Cited by PubMed: 28433539DOI: 10.1016/j.jmb.2017.04.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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