2PB6
 
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | FORMIC ACID, GLYCEROL, Probable diphthine synthase, ... | | Authors: | Yamamoto, H, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-28 | | Release date: | 2007-10-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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2P6O
 | | Crystal structure of TTHB049 from Thermus thermophilus HB8 | | Descriptor: | Alpha-ribazole-5'-phosphate phosphatase | | Authors: | Yamamoto, H, Taketa, M, Tanaka, Y, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-19 | | Release date: | 2007-09-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of TTHB049 from Thermus thermophilus HB8
To be Published
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3D5Q
 | | Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor | | Descriptor: | 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wang, Z, Liu, J, Sudom, A, Walker, N.P.C. | | Deposit date: | 2008-05-16 | | Release date: | 2008-10-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg.Med.Chem., 16, 2008
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4P1W
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4P1N
 | | Crystal structure of Atg1-Atg13 complex | | Descriptor: | Atg1 tMIT, Atg13 MIM | | Authors: | Fujioka, Y, Noda, N.N. | | Deposit date: | 2014-02-27 | | Release date: | 2014-05-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of starvation-induced assembly of the autophagy initiation complex.
Nat.Struct.Mol.Biol., 21, 2014
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4RYD
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6SWA
 | | Mus musculus brain neocortex ribosome 60S bound to Ebp1 | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Kraushar, M.L, Sprink, T. | | Deposit date: | 2019-09-20 | | Release date: | 2020-09-30 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
Mol.Cell, 81, 2021
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7JLQ
 | | cryo-EM structure of human ATG9A in LMNG micelles | | Descriptor: | Autophagy-related protein 9A | | Authors: | Maeda, S, Otomo, T. | | Deposit date: | 2020-07-30 | | Release date: | 2020-10-28 | | Last modified: | 2020-12-16 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
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7JLO
 | | Cryo-EM structure of human ATG9A in amphipols | | Descriptor: | Autophagy-related protein 9A | | Authors: | Maeda, S, Otomo, T. | | Deposit date: | 2020-07-30 | | Release date: | 2020-10-28 | | Last modified: | 2020-12-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
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7JLP
 | | cryo-EM structure of human ATG9A in nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Autophagy-related protein 9A | | Authors: | Maeda, S, Otomo, T. | | Deposit date: | 2020-07-30 | | Release date: | 2020-10-28 | | Last modified: | 2020-12-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
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2D5G
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3VX8
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1UK1
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3VU4
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8HAR
 | | SAH-bound C-Methyltransferase Fur6 from Streptomyces sp. KO-3988 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fur6, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Noguchi, T, Nagata, R, Tomita, T, Kuzuyama, T. | | Deposit date: | 2022-10-26 | | Release date: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Reductive biosynthesis of meroterpenoids via transient diazotization
To Be Published
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5Z5S
 | | Crystal structure of the PPARgamma-LBD complexed with compound 13ab | | Descriptor: | 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | | Authors: | Matsui, Y, Hanzawa, H. | | Deposit date: | 2018-01-19 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of DS-6930, a potent selective PPAR gamma modulator. Part I: Lead identification.
Bioorg. Med. Chem., 26, 2018
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5Z6S
 | | Crystal structure of the PPARgamma-LBD complexed with compound DS-6930 | | Descriptor: | 3-[[6-(3,5-dimethylpyridin-2-yl)oxy-1-methyl-benzimidazol-2-yl]methoxy]benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | | Authors: | Matsui, Y, Hanzawa, H. | | Deposit date: | 2018-01-25 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of DS-6930, a potent selective PPAR gamma modulator. Part II: Lead optimization.
Bioorg. Med. Chem., 26, 2018
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3WW6
 | | Crystal Structure of hen egg white lysozyme mutant N46D/D52S | | Descriptor: | CHLORIDE ION, Lysozyme C | | Authors: | Abe, Y, Kubota, M, Ito, Y, Imoto, T, Ueda, T. | | Deposit date: | 2014-06-17 | | Release date: | 2015-06-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Effect on catalysis by replacement of catalytic residue from hen egg white lysozyme to Venerupis philippinarum lysozyme.
Protein Sci., 25, 2016
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3WW5
 | | Crystal Structure of hen egg white lysozyme mutant N46E/D52S | | Descriptor: | CHLORIDE ION, Lysozyme C | | Authors: | Abe, Y, Kubota, M, Ito, Y, Imoto, T, Ueda, T. | | Deposit date: | 2014-06-17 | | Release date: | 2015-06-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Effect on catalysis by replacement of catalytic residue from hen egg white lysozyme to Venerupis philippinarum lysozyme.
Protein Sci., 25, 2016
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3W6X
 | | Yeast N-acetyltransferase Mpr1 in complex with CHOP | | Descriptor: | (4S)-4-hydroxy-L-proline, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... | | Authors: | Nasuno, R, Hirano, Y, Itoh, T, Hakoshima, T, Hibi, T, Takagi, H. | | Deposit date: | 2013-02-25 | | Release date: | 2013-08-07 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.299 Å) | | Cite: | Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism
Proc.Natl.Acad.Sci.USA, 110, 2013
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3W6S
 | | yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism | | Descriptor: | HEXAETHYLENE GLYCOL, MAGNESIUM ION, MPR1 protein | | Authors: | Nasuno, R, Hirano, Y, Itoh, T, Hakoshima, T, Hibi, T, Takagi, H. | | Deposit date: | 2013-02-21 | | Release date: | 2013-07-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism
Proc.Natl.Acad.Sci.USA, 110, 2013
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2EQQ
 | | Solution structure of growth-blocking peptide of the armyworm, Pseudaletia separata | | Descriptor: | Growth-blocking peptide, long form | | Authors: | Umetsu, Y, Aizawa, T, Kamiya, M, Kumaki, Y, Demura, M, Kawano, K. | | Deposit date: | 2007-03-30 | | Release date: | 2008-04-01 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | C-terminal elongation of growth-blocking peptide enhances its biological activity and micelle binding affinity
J.Biol.Chem., 284, 2009
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2EQH
 | | Solution structure of growth-blocking peptide of the armyworm, Pseudaletia separata | | Descriptor: | Growth-blocking peptide, short form | | Authors: | Umetsu, Y, Aizawa, T, Kamiya, M, Kumaki, Y, Demura, M, Kawano, K. | | Deposit date: | 2007-03-30 | | Release date: | 2008-04-01 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | C-terminal elongation of growth-blocking peptide enhances its biological activity and micelle binding affinity
J.Biol.Chem., 284, 2009
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2EQT
 | | Micelle-bound structure of growth-blocking peptide of the armyworm, Pseudaletia separata | | Descriptor: | Growth-blocking peptide, long form | | Authors: | Umetsu, Y, Aizawa, T, Kamiya, M, Kumaki, Y, Demura, M, Kawano, K. | | Deposit date: | 2007-03-30 | | Release date: | 2008-04-01 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | C-terminal elongation of growth-blocking peptide enhances its biological activity and micelle binding affinity
J.Biol.Chem., 284, 2009
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7C3N
 | | Crystal structure of JAK3 in complex with Delgocitinib | | Descriptor: | 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile, Tyrosine-protein kinase JAK3 | | Authors: | Doi, S, Otira, T, Kikuwaka, M, Nomura, A, Noji, S, Adachi, T. | | Deposit date: | 2020-05-13 | | Release date: | 2020-06-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
J.Med.Chem., 63, 2020
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