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1UK1

Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor

Summary for 1UK1
Entry DOI10.2210/pdb1uk1/pdb
Related1UK0
DescriptorPoly [ADP-ribose] polymerase-1, 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE (3 entities in total)
Functional Keywordsprotein-inhibitor complex, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P09874
Total number of polymer chains2
Total formula weight79180.63
Authors
Kinoshita, T. (deposition date: 2003-08-14, release date: 2004-09-14, Last modification date: 2023-12-27)
Primary citationHattori, K.,Kido, Y.,Yamamoto, H.,Ishida, J.,Kamijo, K.,Murano, K.,Ohkubo, M.,Kinoshita, T.,Iwashita, A.,Mihara, K.,Yamazaki, S.,Matsuoka, N.,Teramura, Y.,Miyake, H.
Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase
J.Med.Chem., 47:4151-4154, 2004
Cited by
PubMed: 15293985
DOI: 10.1021/jm0499256
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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