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1UK1

Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
B0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE FRQ A 501
ChainResidue
AASP766
APHE897
AALA898
ASER904
ATYR907
AGLU988
ALEU769
ATRP861
AHIS862
AGLY863
AARG878
AILE879
AALA880
ATYR889

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE FRQ B 502
ChainResidue
BASP766
BASP770
BTRP861
BHIS862
BGLY863
BILE879
BTYR889
BTYR896
BPHE897
BALA898
BLYS903
BSER904
BTYR907
BGLU988

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues234
DetailsDomain: {"description":"PARP alpha-helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00398","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7852410","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9315851","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9UGN5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a26
ChainResidueDetails
ATYR907
AGLU988

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a26
ChainResidueDetails
BTYR907
BGLU988

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PDB entries from 2025-10-15

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