5Z5S

Crystal structure of the PPARgamma-LBD complexed with compound 13ab

Summary for 5Z5S

Entry DOI	10.2210/pdb5z5s/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid, ... (5 entities in total)
Functional Keywords	transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	34977.69
Authors	Matsui, Y.,Hanzawa, H. (deposition date: 2018-01-19, release date: 2018-10-17, Last modification date: 2023-11-22)
Primary citation	Shinozuka, T.,Tsukada, T.,Fujii, K.,Tokumaru, E.,Shimada, K.,Onishi, Y.,Matsui, Y.,Wakimoto, S.,Kuroha, M.,Ogata, T.,Araki, K.,Ohsumi, J.,Sawamura, R.,Watanabe, N.,Yamamoto, H.,Fujimoto, K.,Tani, Y.,Mori, M.,Tanaka, J. Discovery of DS-6930, a potent selective PPAR gamma modulator. Part I: Lead identification. Bioorg. Med. Chem., 26:5079-5098, 2018 Cited by PubMed: 30241907 DOI: 10.1016/j.bmc.2018.09.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation