5Z5S
Crystal structure of the PPARgamma-LBD complexed with compound 13ab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 283 | 32412.6 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | B (C) | Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 19 | 2067.4 | 1 | UniProt (Q9UBK2) | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 |
| 3 | C (A) | 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid | non-polymer | 426.8 | 1 | Chemie (RTE) | |||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G (A, C) | water | water | 18.0 | 264 | Chemie (HOH) |
Sequence modifications
A: 206 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 195 | - | expression tag |
| Arg 196 | - | expression tag |
| Gly 197 | - | expression tag |
| Ser 198 | - | expression tag |
| His 199 | - | expression tag |
| His 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
| Gly 205 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34480.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 497.7 | |
| All* | Total formula weight | 34977.7 |
