5Z5S

Crystal structure of the PPARgamma-LBD complexed with compound 13ab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peroxisome proliferator-activated receptor gamma	polymer	283	32412.6	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	C	Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	polymer	19	2067.4	1	UniProt (Q9UBK2) In PDB	Homo sapiens	PPARGC-1-alpha,Ligand effect modulator 6
3	A	3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid	non-polymer		426.8	1	Chemie (RTE)
4	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5		water	water		18.0	264	Chemie (HOH)

Sequence modifications

A: 206 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 195	-	expression tag
Arg 196	-	expression tag
Gly 197	-	expression tag
Ser 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
Gly 205	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34480.0
Non-Polymers*	Number of molecules	3
	Total formula weight	497.7
All*	Total formula weight	34977.7

*Water molecules are not included.