3D5Q

Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor

Summary for 3D5Q

• Entry DOI: 10.2210/pdb3d5q/pdb
• Related: 3CZR 3D3E 3D4N
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole (3 entities in total)
• Functional Keywords: oxidoreductase, 11beta, hydroxysteroid, dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• Total number of polymer chains: 4
• Total formula weight: 124510.60

Authors

Wang, Z.,Liu, J.,Sudom, A.,Walker, N.P.C. (deposition date: 2008-05-16, release date: 2008-10-07, Last modification date: 2024-02-21)

• Primary citation: Tu, H.,Powers, J.P.,Liu, J.,Ursu, S.,Sudom, A.,Yan, X.,Xu, H.,Meininger, D.,Degraffenreid, M.,He, X.,Jaen, J.C.,Sun, D.,Labelle, M.,Yamamoto, H.,Shan, B.,Walker, N.P.,Wang, Z.; Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.; Bioorg.Med.Chem., 16:8922-8931, 2008; PubMed: 18789704; DOI: 10.1016/j.bmc.2008.08.065

Experimental method

X-RAY DIFFRACTION (2.55 Å)