3D5Q
Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 272 | 29978.9 | 4 | UniProt (P28845) Pfam (PF00106) | Homo sapiens (Human) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1 |
| 2 | E, G, I, K (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, H, J, L (A, B, C, D) | 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole | non-polymer | 405.4 | 4 | Chemie (T30) |
Sequence modifications
A, B, C, D: 24 - 292 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Gln 21 | - | expression tag |
| Pro 22 | - | expression tag |
| Leu 23 | - | expression tag |
| Ser 272 | Cys 272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119915.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4595.2 | |
| All* | Total formula weight | 124510.6 |
