6EGA
| IRAK4 in complex with a type II inhibitor | 分子名称: | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Wang, L, Wu, H. | 登録日 | 2018-08-19 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.512 Å) | 主引用文献 | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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6EG9
| IRAK4 in complex with Ponatinib | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Wang, L, Wu, H. | 登録日 | 2018-08-19 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.414 Å) | 主引用文献 | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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6EGE
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6EGD
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6EGF
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2BW7
| A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen | 分子名称: | 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE, ADENYLATE CYCLASE, CALCIUM ION, ... | 著者 | Steegborn, C, Litvin, T.N, Hess, K.C, Capper, A.B, Taussig, R, Buck, J, Levin, L.R, Wu, H. | 登録日 | 2005-07-12 | 公開日 | 2005-07-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen J.Biol.Chem., 280, 2005
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3HCS
| Crystal structure of the N-terminal domain of TRAF6 | 分子名称: | TNF receptor-associated factor 6, ZINC ION | 著者 | Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. | 登録日 | 2009-05-06 | 公開日 | 2009-05-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | E2 interaction and dimerization in the crystal structure of TRAF6. Nat.Struct.Mol.Biol., 16, 2009
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1QR6
| HUMAN MITOCHONDRIAL NAD(P)-DEPENDENT MALIC ENZYME | 分子名称: | MALIC ENZYME 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Xu, Y, Bhargava, G, Wu, H, Loeber, G, Tong, L. | 登録日 | 1999-06-18 | 公開日 | 1999-07-05 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases. Structure, 7, 1999
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3HCT
| Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group | 分子名称: | TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION | 著者 | Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. | 登録日 | 2009-05-06 | 公開日 | 2009-05-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | E2 interaction and dimerization in the crystal structure of TRAF6. Nat.Struct.Mol.Biol., 16, 2009
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3I6K
| Newly identified epitope from SARS-CoV membrane protein complexed with HLA-A*0201 | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | 著者 | Liu, J, Sun, Y, Qi, J, Chu, F, Wu, H, Gao, F, Li, T, Yan, J, Gao, G.F. | 登録日 | 2009-07-07 | 公開日 | 2010-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes J Infect Dis, 202, 2010
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3UR4
| Crystal structure of human WD repeat domain 5 with compound | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | 著者 | Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-11-21 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
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6VFE
| Gasdermin D pore | 分子名称: | Gasdermin-D, N-terminal | 著者 | Xia, S, Ruan, J, Wu, H. | 登録日 | 2020-01-03 | 公開日 | 2021-04-21 | 最終更新日 | 2021-06-09 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature, 593, 2021
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2BBZ
| Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition | 分子名称: | Viral CASP8 and FADD-like apoptosis regulator | 著者 | Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H. | 登録日 | 2005-10-18 | 公開日 | 2006-02-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol.Cell, 20, 2005
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3IHX
| Methyltransferase domain of human PR domain-containing protein 10 | 分子名称: | PR domain zinc finger protein 10 | 著者 | Amaya, M.F, Dombrovski, L, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-07-31 | 公開日 | 2009-08-18 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Methyltransferase domain of human PR domain-containing protein 10 To be Published
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3RAY
| Crystal structure of Methyltransferase domain of human PR domain-containing protein 11 | 分子名称: | CHLORIDE ION, PR domain-containing protein 11, SODIUM ION, ... | 著者 | Dong, A, Zeng, H, Loppnau, P, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-03-28 | 公開日 | 2011-04-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal structure of Methyltransferase domain of human PR domain-containing protein 11 To be Published
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6W8N
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6W8P
| Structure of membrane protein with ions | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | 著者 | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | 登録日 | 2020-03-21 | 公開日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of membrane protein with ions To Be Published
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6W8O
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4JDS
| SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine | 分子名称: | Histone-lysine N-methyltransferase SETD7, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, S-ADENOSYLMETHIONINE, ... | 著者 | Dong, A, Wu, H, Zeng, H, Park, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2013-02-25 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine to be published
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1Z4R
| Human GCN5 Acetyltransferase | 分子名称: | ACETYL COENZYME *A, General control of amino acid synthesis protein 5-like 2 | 著者 | Dong, A, Bernstein, G, Schuetz, A, Antoshenko, T, Wu, H, Loppnau, P, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Plotnikov, A, Structural Genomics Consortium (SGC) | 登録日 | 2005-03-16 | 公開日 | 2005-03-29 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A Proteins, 68, 2007
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6D2L
| Crystal structure of human CARM1 with (S)-SKI-72 | 分子名称: | (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | 著者 | DONG, A, ZENG, H, WALKER, J.R, Hutchinson, A, Seitova, A, LUO, M, CAI, X.C, KE, W, WANG, J, SHI, C, ZHENG, W, LEE, J.P, IBANEZ, G, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2018-04-13 | 公開日 | 2018-05-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife, 8, 2019
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3HCU
| Crystal structure of TRAF6 in complex with Ubc13 in the C2 space group | 分子名称: | TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION | 著者 | Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. | 登録日 | 2009-05-06 | 公開日 | 2009-05-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | E2 interaction and dimerization in the crystal structure of TRAF6. Nat.Struct.Mol.Biol., 16, 2009
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2BBR
| Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition | 分子名称: | AZIDE ION, Viral CASP8 and FADD-like apoptosis regulator | 著者 | Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H. | 登録日 | 2005-10-17 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol.Cell, 20, 2005
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3J63
| Unified assembly mechanism of ASC-dependent inflammasomes | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | 著者 | Lu, A, Magupalli, V.G, Ruan, J, Yin, Q, Atianand, M.K, Vos, M, Schroder, G.F, Fitzgerald, K.A, Wu, H, Egelman, E.H. | 登録日 | 2013-12-05 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell(Cambridge,Mass.), 156, 2014
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3QKW
| Structure of Streptococcus parasangunini Gtf3 glycosyltransferase | 分子名称: | Nucleotide sugar synthetase-like protein, URIDINE-5'-DIPHOSPHATE | 著者 | Zhu, F, Erlandsen, H, Huang, Y, Ding, L, Zhou, M, Liang, X, Ma, J.-B, Wu, H. | 登録日 | 2011-02-01 | 公開日 | 2011-06-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.287 Å) | 主引用文献 | Structural and Functional Analysis of a New Subfamily of Glycosyltransferases Required for Glycosylation of Serine-rich Streptococcal Adhesins. J.Biol.Chem., 286, 2011
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