7XHV
| Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ... | 著者 | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | 登録日 | 2022-04-10 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.996 Å) | 主引用文献 | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7XI3
| Crystal Structure of the NPAS4-ARNT2 heterodimer in complex with DNA | 分子名称: | Aryl hydrocarbon receptor nuclear translocator 2, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ... | 著者 | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | 登録日 | 2022-04-11 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.274 Å) | 主引用文献 | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7XI4
| Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), ... | 著者 | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | 登録日 | 2022-04-12 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.707 Å) | 主引用文献 | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
6KI0
| Crystal Structure of Human ASC-CARD | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Xu, Z.H, Jin, T.C. | 登録日 | 2019-07-16 | 公開日 | 2020-07-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis, 12, 2021
|
|
6L8L
| C-Src in complex with ibrutinib | 分子名称: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, Proto-oncogene tyrosine-protein kinase Src | 著者 | Guo, M, Dai, S, Chen, L, Chen, Y. | 登録日 | 2019-11-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.888 Å) | 主引用文献 | Characterization of ibrutinib as a non-covalent inhibitor of SRC-family kinases. Bioorg.Med.Chem.Lett., 34, 2020
|
|
1I1I
| NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE | 分子名称: | NEUROLYSIN, ZINC ION | 著者 | Brown, C.K, Madauss, K, Lian, W, Tolbert, W.D, Beck, M.R, Rodgers, D.W. | 登録日 | 2001-02-01 | 公開日 | 2001-02-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of neurolysin reveals a deep channel that limits substrate access. Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
6OQV
| E. coli ATP Synthase State 2b | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Stewart, A.G, Sobti, M, Walshe, J.L. | 登録日 | 2019-04-29 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
|
|
6OQR
| E. coli ATP Synthase ADP State 1a | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Stewart, A.G, Walshe, J.L, Sobti, M. | 登録日 | 2019-04-29 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
|
|
6OQU
| E. coli ATP synthase State 1d | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Stewart, A.G, Sobti, M, Walshe, J.L. | 登録日 | 2019-04-29 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
|
|
6OQS
| E. coli ATP synthase State 1b | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Stewart, A.G, Sobti, M, Walshe, J.L. | 登録日 | 2019-04-29 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
|
|
6OQW
| E. coli ATP synthase State 3a | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Stewart, A.G, Sobti, M, Walshe, J.L. | 登録日 | 2019-04-29 | 公開日 | 2020-06-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
|
|
2JTK
| |
7WBB
| Cryo-EM structure of substrate engaged Drg1 hexamer | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, AFG2 isoform 1, substrate | 著者 | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | 登録日 | 2021-12-16 | 公開日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7WD3
| Cryo-EM structure of Drg1 hexamer treated with ATP and benzo-diazaborine | 分子名称: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | 著者 | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | 登録日 | 2021-12-21 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7YKZ
| Cryo-EM structure of Drg1 hexamer in the planar state treated with ADP/AMPPNP/Diazaborine | 分子名称: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | 登録日 | 2022-07-25 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7YKL
| Cryo-EM structure of Drg1 hexamer treated with AMPPNP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | 著者 | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | 登録日 | 2022-07-22 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7YKT
| Cryo-EM structure of Drg1 hexamer in helical state treated with ADP/AMPPNP/benzo-diazaborine | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | 著者 | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | 登録日 | 2022-07-23 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7YKK
| Cryo-EM structure of Drg1 hexamer treated with ADP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | 著者 | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | 登録日 | 2022-07-22 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
5WRE
| Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01) | 分子名称: | (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | 著者 | Zhou, Z, Xu, Z.H. | 登録日 | 2016-12-01 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7, 2017
|
|
5WQA
| Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K | 分子名称: | 1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y, Zhang, T, Zheng, X, Yin, S, Luo, H.B. | 登録日 | 2016-11-24 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata Biochem. Pharmacol., 130, 2017
|
|
5ZXD
| Crystal structure of ATP-bound human ABCF1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family F member 1 | 著者 | Qu, L, Jiang, Y, Liu, Z.J. | 登録日 | 2018-05-18 | 公開日 | 2018-07-25 | 最終更新日 | 2018-09-19 | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | 主引用文献 | Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins Structure, 26, 2018
|
|
3B7J
| Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone | 分子名称: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 5-hydroxynaphthalene-1,4-dione, BENZAMIDINE, ... | 著者 | Zhang, L, Kong, Y.H, Wu, D, Shen, X, Jiang, H.L. | 登録日 | 2007-10-31 | 公開日 | 2008-09-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization ACTA PHARMACOL.SIN., 29, 2008
|
|
4IQR
| Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA | 分子名称: | DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... | 著者 | Chandra, V, Huang, P, Kim, Y, Rastinejad, F. | 登録日 | 2013-01-13 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013
|
|
7YF1
| |
5T2P
| Hepatitis B virus core protein Y132A mutant in complex with sulfamoylbenzamide (SBA_R01) | 分子名称: | 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-~{N}-[3,4,5-tris(fluoranyl)phenyl]benzamide, CHLORIDE ION, Core protein, ... | 著者 | Zhou, Z, Xu, Z.H. | 登録日 | 2016-08-24 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.693 Å) | 主引用文献 | Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7, 2017
|
|