6KI0

Crystal Structure of Human ASC-CARD

Summary for 6KI0

• Entry DOI: 10.2210/pdb6ki0/pdb
• Related PRD ID: PRD_900009
• Descriptor: Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total)
• Functional Keywords: death domain fold, immune system
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 2
• Total formula weight: 104277.57

Authors

Xu, Z.H.,Jin, T.C. (deposition date: 2019-07-16, release date: 2020-07-22, Last modification date: 2023-11-22)

• Primary citation: Xu, Z.,Zhou, Y.,Liu, M.,Ma, H.,Sun, L.,Zahid, A.,Chen, Y.,Zhou, R.,Cao, M.,Wu, D.,Zhao, W.,Li, B.,Jin, T.; Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.; Cell Death Dis, 12:57-57, 2021; PubMed: 33431827; DOI: 10.1038/s41419-020-03342-8

Experimental method

X-RAY DIFFRACTION (2 Å)