6KI0
Crystal Structure of Human ASC-CARD
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD | polymer | 466 | 51490.3 | 2 | UniProt (P0AEX9) UniProt (Q9ULZ3) Pfam (PF01547) Pfam (PF00619) In PDB | Escherichia coli (strain K12) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,hASC,Caspase recruitment domain-containing protein 5,PYD and CARD domain-containing protein,Target of methylation-induced silencing 1 |
2 | C, D | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 504.4 | 2 | In PDB BIRD (PRD_900009) GlyTouCan (G96370VA) | alpha-maltotriose | ||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
4 | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 358 (UniProt: P0AEX9)
A, B: 371 - 454 (UniProt: Q9ULZ3)
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
Ala 82 | Asp 108 | engineered mutation |
Ala 83 | Lys 109 | engineered mutation |
Ala 172 | Glu 198 | engineered mutation |
Ala 173 | Asn 199 | engineered mutation |
Ala 239 | Lys 265 | engineered mutation |
Ala 359 | - | linker |
Ala 360 | - | linker |
Leu 361 | - | linker |
Ala 362 | - | linker |
Ala 363 | - | linker |
Ala 364 | - | linker |
Gln 365 | - | linker |
Thr 366 | - | linker |
Asn 367 | - | linker |
Ala 368 | - | linker |
Val 369 | - | linker |
Asp 370 | - | linker |
PDB | External Database | Details |
---|---|---|
Ala 455 | - | expression tag |
Ala 456 | - | expression tag |
Ala 457 | - | expression tag |
Leu 458 | - | expression tag |
Glu 459 | - | expression tag |
His 460 | - | expression tag |
His 461 | - | expression tag |
His 462 | - | expression tag |
His 463 | - | expression tag |
His 464 | - | expression tag |
His 465 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 102980.5 | |
Branched | Number of molecules | 2 |
Total formula weight | 1008.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 288.2 | |
All* | Total formula weight | 104277.6 |