5WRE

Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01)

Summary for 5WRE

• Entry DOI: 10.2210/pdb5wre/pdb
• Descriptor: Core protein, (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, ISOPROPYL ALCOHOL, ... (6 entities in total)
• Functional Keywords: hepatitis b virus, hbv, core protein, capsid, y132a dimer, y132a hexamer, heteroaryldihydropyrimidine, hap, viral protein
• Biological source: Hepatitis B virus (HBV)
• Total number of polymer chains: 6
• Total formula weight: 109090.51

Authors

Zhou, Z.,Xu, Z.H. (deposition date: 2016-12-01, release date: 2017-02-22, Last modification date: 2023-11-08)

• Primary citation: Zhou, Z.,Hu, T.,Zhou, X.,Wildum, S.,Garcia-Alcalde, F.,Xu, Z.,Wu, D.,Mao, Y.,Tian, X.,Zhou, Y.,Shen, F.,Zhang, Z.,Tang, G.,Najera, I.,Yang, G.,Shen, H.C.,Young, J.A.,Qin, N.; Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.; Sci Rep, 7:42374-42374, 2017; PubMed: 28205569; DOI: 10.1038/srep42374

Experimental method

X-RAY DIFFRACTION (1.946 Å)