5WRE
Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Core protein | polymer | 155 | 17486.9 | 6 | UniProt (L7R9I1) Pfam (PF00906) In PDB | Hepatitis B virus (HBV) | |
| 2 | A, B, C, D, E... | (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid | non-polymer | 514.9 | 6 | Chemie (7TL) | |||
| 3 | A, C, D, E | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 7 | Chemie (IPA) | |||
| 4 | B, D | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | F, B, C, E | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 504 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 149 (UniProt: L7R9I1)
| PDB | External Database | Details |
|---|---|---|
| Ala 132 | Tyr 132 | engineered mutation |
| Glu 150 | - | expression tag |
| Asn 151 | - | expression tag |
| Leu 152 | - | expression tag |
| Tyr 153 | - | expression tag |
| Phe 154 | - | expression tag |
| Gln 155 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 104921.5 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 4169.0 | |
| All* | Total formula weight | 109090.5 |
