7WRV
| The interface of JMB2002 Fab binds to SARS-CoV-2 Omicron Variant S | Descriptor: | JMB2002 Fab heavy chain, JMB2002 Fab light chain, Spike glycoprotein | Authors: | Yin, W, Xu, Y, Xu, P, Cao, X, Wu, C, Gu, C, He, X, Wang, X, Huang, S, Yuan, Q, Wu, K, Hu, W, Huang, Z, Liu, J, Wang, Z, Jia, F, Xia, K, Liu, P, Wang, X, Song, B, Zheng, J, Jiang, H, Cheng, X, Jiang, Y, Deng, S.J, Xu, H.E. | Deposit date: | 2022-01-27 | Release date: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (2.47 Å) | Cite: | Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody. Science, 375, 2022
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7WPF
| SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Fab nanobody, ... | Authors: | Yin, W, Xu, Y, Xu, P, Cao, X, Wu, C, Gu, C, He, X, Wang, X, Huang, S, Yuan, Q, Wu, K, Hu, W, Huang, Z, Liu, J, Wang, Z, Jia, F, Xia, K, Liu, P, Wang, X, Song, B, Zheng, J, Jiang, H, Cheng, X, Jiang, Y, Deng, S.J, Xu, H.E. | Deposit date: | 2022-01-23 | Release date: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody. Science, 375, 2022
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1U5S
| NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain | Descriptor: | Cytoplasmic protein NCK2, PINCH protein, ZINC ION | Authors: | Vaynberg, J, Fukuda, T, Vinogradova, O, Velyvis, A, Ng, L, Wu, C, Qin, J. | Deposit date: | 2004-07-28 | Release date: | 2005-04-05 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility. Mol.Cell, 17, 2005
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5Z0R
| Structural insight into the Zika virus capsid encapsulating the viral genome | Descriptor: | Extracellular solute-binding protein family 1,viral genome protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Li, T, Zhao, Q, Yang, X, Chen, C, Yang, K, Wu, C, Zhang, T, Duan, Y, Xue, X, Mi, K, Ji, X, Wang, Z, Yang, H. | Deposit date: | 2017-12-20 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural insight into the Zika virus capsid encapsulating the viral genome. Cell Res., 28, 2018
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1MN4
| Structure of Ndt80 (Residues 59-340) DNA-binding domain core | Descriptor: | NDT80 PROTEIN | Authors: | Lamoureux, J.S, Stuart, D, Tsang, R, Wu, C, Glover, J.N.M. | Deposit date: | 2002-09-04 | Release date: | 2002-11-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the sporulation-specific transcription factor Ndt80 bound to DNA Embo J., 21, 2002
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1X9X
| Solution Structure of Dimeric SAM Domain from MAPKKK Ste11 | Descriptor: | Serine/threonine-protein kinase STE11 | Authors: | Bhattacharjya, S, Xu, P, Gingras, R, Shaykhutdinov, R, Wu, C, Whiteway, M, Ni, F. | Deposit date: | 2004-08-24 | Release date: | 2005-08-30 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of the dimeric SAM domain of MAPKKK Ste11 and its interactions with the adaptor protein Ste50 from the budding yeast: implications for Ste11 activation and signal transmission through the Ste50-Ste11 complex. J.Mol.Biol., 344, 2004
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3MAZ
| Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide | Descriptor: | CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 | Authors: | Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. | Deposit date: | 2010-03-24 | Release date: | 2010-05-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
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1NYP
| 4th LIM domain of PINCH protein | Descriptor: | PINCH protein, ZINC ION | Authors: | Velyvis, A, Vaynberg, J, Vinogradova, O, Zhang, Y, Wu, C, Qin, J. | Deposit date: | 2003-02-13 | Release date: | 2003-07-01 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling Nat.Struct.Biol., 10, 2003
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7XO4
| SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with two mouse ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-04-30 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOA
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with one mouse ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO9
| SARS-CoV-2 Omicron BA.2 Variant RBD complexed with human ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO5
| SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with one mouse ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO7
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two human ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOD
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of JMB2002 Fab, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO8
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three human ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO6
| SARS-CoV-2 Omicron BA.1 Variant RBD with mouse ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOC
| SARS-CoV-2 Omicron BA.2 Variant RBD complexed with mouse ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOB
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two mouse ACE2 Bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | Authors: | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | Deposit date: | 2022-05-01 | Release date: | 2022-06-15 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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1G47
| 1ST LIM DOMAIN OF PINCH PROTEIN | Descriptor: | PINCH PROTEIN, ZINC ION | Authors: | Velyvis, A, Yang, Y, Wu, C, Qin, J. | Deposit date: | 2000-10-26 | Release date: | 2001-02-21 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. J.Biol.Chem., 276, 2001
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5Z0V
| Structural insight into the Zika virus capsid encapsulating the viral genome | Descriptor: | Extracellular solute-binding protein family 1,viral genome protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Li, T, Zhao, Q, Yang, X, Chen, C, Yang, K, Wu, C, Zhang, T, Duan, Y, Xue, X, Mi, K, Ji, X, Wang, Z, Yang, H. | Deposit date: | 2017-12-21 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.913 Å) | Cite: | Structural insight into the Zika virus capsid encapsulating the viral genome. Cell Res., 28, 2018
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7YDX
| Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | Descriptor: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | Authors: | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | Deposit date: | 2022-07-04 | Release date: | 2023-04-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.642 Å) | Cite: | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun, 13, 2022
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6KPP
| BNC105 in complex with tubulin | Descriptor: | (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, T, Wu, C, Pu, D. | Deposit date: | 2019-08-15 | Release date: | 2020-08-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.74524117 Å) | Cite: | Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020
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3HTP
| the hemagglutinin structure of an avian H1N1 influenza A virus in complex with LSTa | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Wang, G, Li, A, Zhang, Q, Wu, C, Zhang, R, Cai, Q, Song, W, Yuen, K.-Y. | Deposit date: | 2009-06-12 | Release date: | 2009-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | The hemagglutinin structure of an avian H1N1 influenza A virus Virology, 392, 2009
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3HTO
| the hemagglutinin structure of an avian H1N1 influenza A virus | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Wang, G, Li, A, Zhang, Q, Wu, C, Zhang, R, Cai, Q, Song, W, Yuen, K.-Y. | Deposit date: | 2009-06-12 | Release date: | 2009-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | The hemagglutinin structure of an avian H1N1 influenza A virus Virology, 392, 2009
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3HTQ
| the hemagglutinin structure of an avian H1N1 influenza A virus in complex with LSTc | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Wang, G, Li, A, Zhang, Q, Wu, C, Zhang, R, Cai, Q, Song, W, Yuen, K.-Y. | Deposit date: | 2009-06-12 | Release date: | 2009-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | The hemagglutinin structure of an avian H1N1 influenza A virus Virology, 392, 2009
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