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4O91
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BU of 4o91 by Molmil
Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1
分子名称: Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
著者Gurbani, D, Hunter, J.C, Tan, L, Westover, K.D.
登録日2013-12-31
公開日2014-07-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.393 Å)
主引用文献Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2).
J.Med.Chem., 58, 2015
2E2J
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BU of 2e2j by Molmil
RNA polymerase II elongation complex in 5 mM Mg+2 with GMPCPP
分子名称: 27-MER DNA template strand, 5'-D(P*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*A)-3', 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2E2H
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BU of 2e2h by Molmil
RNA polymerase II elongation complex at 5 mM Mg2+ with GTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2E2I
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BU of 2e2i by Molmil
RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.41 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
4QL3
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BU of 4ql3 by Molmil
Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-06-10
公開日2015-06-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.041 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
4TQ9
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BU of 4tq9 by Molmil
Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-06-10
公開日2015-06-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.491 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
4TQA
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BU of 4tqa by Molmil
Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-06-10
公開日2015-06-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
6MQT
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BU of 6mqt by Molmil
HRAS G12S in complex with GDP
分子名称: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Bera, A.K, Westover, K.D.
登録日2018-10-10
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.498 Å)
主引用文献HRAS G12S in complex with GDP
To Be Published
6MNX
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BU of 6mnx by Molmil
Structural basis of impaired hydrolysis in KRAS Q61H mutant
分子名称: GTPase KRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Bera, A.K, Westover, K.D.
登録日2018-10-03
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献KRASQ61HPreferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer.
Cancer Res., 80, 2020
6MTA
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BU of 6mta by Molmil
KRAS P34R mutant structure in complex with GTP analogue
分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Bera, A.K, Westover, K.D.
登録日2018-10-19
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
Birth Defects Res, 112, 2020
6MQN
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BU of 6mqn by Molmil
Crystal structure of KRAS V14I-GDP demonstrating disorder switch 1 conformation - Form 2
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
著者Bera, A.K, Westover, K.D.
登録日2018-10-10
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis of the atypical activation mechanism of KRASV14I.
J.Biol.Chem., 294, 2019
6MS9
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BU of 6ms9 by Molmil
GDP-bound KRAS P34R mutant
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Bera, A.K, Westover, K.D.
登録日2018-10-16
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
Birth Defects Res, 112, 2020
6MQG
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BU of 6mqg by Molmil
Crystal structure of KRAS V14I-GDP demonstrating open switch 1 conformation - Form 1
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
著者Bera, A.K, Westover, K.D.
登録日2018-10-09
公開日2019-07-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of the atypical activation mechanism of KRASV14I.
J.Biol.Chem., 294, 2019
6O36
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BU of 6o36 by Molmil
Crystal structure of human KRAS P34R mutant in complex with GNP
分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHATE ION, ...
著者Bera, A.K, Westover, K.D.
登録日2019-02-26
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
Birth Defects Res, 112, 2020
6O46
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BU of 6o46 by Molmil
Crystal structure of human KRAS P34R mutant in complex with GNP and Phosphate
分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHATE ION, ...
著者Bera, A.K, Westover, K.D.
登録日2019-02-28
公開日2020-03-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
Birth Defects Res, 112, 2020
2NVT
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BU of 2nvt by Molmil
RNA Polymerase II Elongation Complex in 150 mM Mg+2 with GMPCPP
分子名称: 5'-D(*GP*TP*AP*CP*TP*TP*G)-3', 5'-D(P*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.36 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVY
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BU of 2nvy by Molmil
RNA Polymerase II form II in 150 mM Mn+2
分子名称: DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVZ
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BU of 2nvz by Molmil
RNA Polymerase II elongation complex with UTP, updated 11/2006
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVQ
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BU of 2nvq by Molmil
RNA Polymerase II Elongation Complex in 150 mM Mg+2 with 2'dUTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVX
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BU of 2nvx by Molmil
RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dUTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
3GTL
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BU of 3gtl by Molmil
Backtracked RNA polymerase II complex with 13mer with G<>U mismatch
分子名称: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
3GTJ
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BU of 3gtj by Molmil
Backtracked RNA polymerase II complex with 13mer RNA
分子名称: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
3GTK
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BU of 3gtk by Molmil
Backtracked RNA polymerase II complex with 18mer RNA
分子名称: DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
3GTP
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BU of 3gtp by Molmil
Backtracked RNA polymerase II complex with 24mer RNA
分子名称: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
3GTM
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BU of 3gtm by Molmil
Co-complex of Backtracked RNA polymerase II with TFIIS
分子名称: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009

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