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6XYO
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BU of 6xyo by Molmil
Multiple system atrophy Type I alpha-synuclein filament
Descriptor: Alpha-synuclein
Authors:Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M.
Deposit date:2020-01-30
Release date:2020-02-12
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
6XYP
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BU of 6xyp by Molmil
Multiple system atrophy Type II-1 alpha-synuclein filament
Descriptor: Alpha-synuclein
Authors:Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M.
Deposit date:2020-01-30
Release date:2020-02-12
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
6XYQ
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BU of 6xyq by Molmil
Multiple system atrophy Type II-2 alpha-synuclein filament
Descriptor: Alpha-synuclein
Authors:Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M.
Deposit date:2020-01-30
Release date:2020-02-12
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
7P66
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BU of 7p66 by Molmil
Globular glial tauopathy type 1 tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P6A
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BU of 7p6a by Molmil
Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P6E
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BU of 7p6e by Molmil
Argyrophilic grain disease type 2 tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P6D
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BU of 7p6d by Molmil
Argyrophilic grain disease type 1 tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P68
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BU of 7p68 by Molmil
Globular glial tauopathy type 3 tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P65
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BU of 7p65 by Molmil
Progressive supranuclear palsy tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P6C
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BU of 7p6c by Molmil
Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P67
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BU of 7p67 by Molmil
Globular glial tauopathy type 2 tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
7P6B
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BU of 7p6b by Molmil
Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament
Descriptor: Microtubule-associated protein tau
Authors:Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structure-based classification of tauopathies.
Nature, 598, 2021
8ORG
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BU of 8org by Molmil
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Descriptor: Microtubule-associated protein tau
Authors:Lovestam, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-13
Release date:2023-04-26
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
Febs Open Bio, 13, 2023
8ORE
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BU of 8ore by Molmil
Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Descriptor: Microtubule-associated protein tau
Authors:Lovestam, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-13
Release date:2023-04-26
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
Febs Open Bio, 13, 2023
8ORF
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BU of 8orf by Molmil
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
Descriptor: Microtubule-associated protein tau
Authors:Lovestam, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-13
Release date:2023-04-26
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
Febs Open Bio, 13, 2023
7QWG
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BU of 7qwg by Molmil
TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19)
Descriptor: Transmembrane protein 106B
Authors:Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:2022-01-25
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature, 605, 2022
7QVF
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BU of 7qvf by Molmil
TMEM106B filaments with Fold I-d from Multiple system atrophy (case 18)
Descriptor: Transmembrane protein 106B
Authors:Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:2022-01-21
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature, 605, 2022
7QWM
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BU of 7qwm by Molmil
TMEM106B filaments with Fold III from Multiple system atrophy (case 17)
Descriptor: Transmembrane protein 106B
Authors:Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:2022-01-25
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature, 605, 2022
7QWL
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BU of 7qwl by Molmil
TMEM106B filaments with Fold IIb from Multiple system atrophy (case 19)
Descriptor: Transmembrane protein 106B
Authors:Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:2022-01-25
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature, 605, 2022
7QVC
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BU of 7qvc by Molmil
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Descriptor: Transmembrane protein 106B
Authors:Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:2022-01-21
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature, 605, 2022
6TJO
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BU of 6tjo by Molmil
Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration
Descriptor: Microtubule-associated protein tau
Authors:Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W.
Deposit date:2019-11-26
Release date:2020-02-05
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
6TJX
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BU of 6tjx by Molmil
Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration
Descriptor: Microtubule-associated protein tau
Authors:Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W.
Deposit date:2019-11-27
Release date:2020-02-05
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
7NCA
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BU of 7nca by Molmil
Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
Descriptor: Alpha-synuclein
Authors:Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:2021-01-28
Release date:2021-02-24
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
7NCJ
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BU of 7ncj by Molmil
Type 2AB alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
Descriptor: Alpha-synuclein
Authors:Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:2021-01-28
Release date:2021-02-24
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
7NCG
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BU of 7ncg by Molmil
Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
Descriptor: Alpha-synuclein
Authors:Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:2021-01-28
Release date:2021-02-24
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021

 

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