7QWM

TMEM106B filaments with Fold III from Multiple system atrophy (case 17)

Summary for 7QWM

Entry DOI	10.2210/pdb7qwm/pdb
EMDB information	14189
Descriptor	Transmembrane protein 106B (1 entity in total)
Functional Keywords	amyloid, neurodegeneration, filament, tmem106b, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	93426.88
Authors	Lovestam, S.,Schweighauser, M.,Scheres, S.H.W. (deposition date: 2022-01-25, release date: 2022-03-09, Last modification date: 2022-05-25)
Primary citation	Schweighauser, M.,Arseni, D.,Bacioglu, M.,Huang, M.,Lovestam, S.,Shi, Y.,Yang, Y.,Zhang, W.,Kotecha, A.,Garringer, H.J.,Vidal, R.,Hallinan, G.I.,Newell, K.L.,Tarutani, A.,Murayama, S.,Miyazaki, M.,Saito, Y.,Yoshida, M.,Hasegawa, K.,Lashley, T.,Revesz, T.,Kovacs, G.G.,van Swieten, J.,Takao, M.,Hasegawa, M.,Ghetti, B.,Spillantini, M.G.,Ryskeldi-Falcon, B.,Murzin, A.G.,Goedert, M.,Scheres, S.H.W. Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605:310-314, 2022 Cited by PubMed: 35344985 DOI: 10.1038/s41586-022-04650-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation