6KX4
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6DTL
| Mitogen-activated protein kinase 6 | Descriptor: | Mitogen-activated protein kinase 6 | Authors: | Ruble, J. | Deposit date: | 2018-06-17 | Release date: | 2019-05-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.753 Å) | Cite: | Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP kinases to SPEECHLESS. Nat.Plants, 5, 2019
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6FBV
| Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Das, K, Lin, W, Ebright, E. | Deposit date: | 2017-12-19 | Release date: | 2018-02-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
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6K7D
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6K7E
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6A1C
| Crystal structure of the CK2a1-go289 complex | Descriptor: | 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol, Casein kinase II subunit alpha, ... | Authors: | Kinoshita, T, Tsuyuguchi, M. | Deposit date: | 2018-06-07 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv, 5, 2019
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7D0N
| Crystal structure of mouse CRY2 apo form | Descriptor: | Cryptochrome-2 | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2020-09-11 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DLI
| Crystal structure of mouse CRY1 in complex with KL001 compound | Descriptor: | 1,2-ETHANEDIOL, Cryptochrome-1, N-[(2R)-3-carbazol-9-yl-2-oxidanyl-propyl]-N-(furan-2-ylmethyl)methanesulfonamide | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2020-11-27 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7D0M
| Crystal structure of mouse CRY1 with bound cryoprotectant | Descriptor: | Cryptochrome-1, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2020-09-11 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7EJ9
| Alternative crystal structure of mouse Cryptochrome 2 in complex with TH301 compound | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 | Authors: | Miller, S.A, Hirota, T. | Deposit date: | 2021-04-01 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
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6ASG
| Crystal structure of Thermus thermophilus RNA polymerase core enzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, Y, Lin, W, Ying, R, Ebright, R.H. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
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4NJE
| Crystal structure of Pyrococcus furiosus L-asparaginase with ligand | Descriptor: | ASPARTIC ACID, L-asparaginase | Authors: | Sharma, P, Tomar, R, Singh, S, Yadav, S.P.S, Ashish, Kundu, B. | Deposit date: | 2013-11-09 | Release date: | 2014-12-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains. Acta Crystallogr.,Sect.D, 70, 2014
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4Q0M
| Crystal structure of Pyrococcus furiosus L-asparaginase | Descriptor: | (4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, GLYCEROL, L-asparaginase, ... | Authors: | Sharma, P, Tomar, R, Singh, S, Yadav, S.P.S, Ashish, Kundu, B. | Deposit date: | 2014-04-02 | Release date: | 2014-12-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.226 Å) | Cite: | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains. Acta Crystallogr.,Sect.D, 70, 2014
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4RA9
| Crystal Structure of Conjoint Pyrococcus Furiosus L-asparaginase with Citrate | Descriptor: | CITRATE ANION, GLYCEROL, ISOPROPYL ALCOHOL, ... | Authors: | Sharma, P, Tomar, R, Singh, S, Yadav, S.P.S, Ashish, Kundu, B. | Deposit date: | 2014-09-09 | Release date: | 2014-12-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains. Acta Crystallogr.,Sect.D, 70, 2014
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4RA6
| Crystal structure of linker less Pyrococcus furiosus L-asparaginase | Descriptor: | GLYCEROL, L-asparaginase | Authors: | Sharma, P, Tomar, R, Ashish, Kundu, B. | Deposit date: | 2014-09-09 | Release date: | 2014-12-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains. Acta Crystallogr.,Sect.D, 70, 2014
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6OF7
| Crystal structure of the CRY1-PER2 complex | Descriptor: | Cryptochrome-1, Period circadian protein homolog 2 | Authors: | Michael, A.K, Fribourgh, J.L, Tripathi, S.M, Partch, C.L. | Deposit date: | 2019-03-28 | Release date: | 2020-03-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Elife, 9, 2020
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6X87
| CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. | Descriptor: | 3D11 Fab heavy chain, 3D11 Fab kappa chain, Circumsporozoite protein | Authors: | Kucharska, I, Thai, E, Rubinstein, J, Julien, J.P. | Deposit date: | 2020-06-01 | Release date: | 2020-12-02 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. Elife, 9, 2020
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6X8S
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6X8Q
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6X8U
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6X8P
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8BIK
| Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455 | Descriptor: | (3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-[[6-chloranyl-5-[4-[4-[[dimethyl(oxidanyl)-$l^{4}-sulfanyl]amino]phenyl]phenyl]-3~{H}-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]furan-3-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... | Authors: | Schimpl, M, Mather, K.M, Boland, M.L, Rivers, E.L, Srivastava, A, Hemsley, P, Robinson, J, Wan, P.T, Hansen, J, Read, J.A, Trevaskis, J.L, Smith, D.M. | Deposit date: | 2022-11-02 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Direct AMPK Activator Reduces Liver Steatosis but Does Not Alter Fibrosis in a Mouse Model of Non-Alcoholic Steatohepatitis To be published
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2H02
| Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors | Descriptor: | Protein tyrosine phosphatase, receptor type, B,, ... | Authors: | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Gray, J.L, Peters, K.G, Maier, M.B, Amarasinghe, K.D, Clark, C.M, Nichols, R. | Deposit date: | 2006-05-13 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg.Med.Chem.Lett., 16, 2006
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2H04
| Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors | Descriptor: | Protein tyrosine phosphatase, receptor type, B,, ... | Authors: | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Gray, J.L, Peters, K.G, Maier, M.B, Amarasinghe, K.D, Clark, C.M, Nichols, R. | Deposit date: | 2006-05-13 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg.Med.Chem.Lett., 16, 2006
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2H03
| Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors | Descriptor: | (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Gray, J.L, Peters, K.G, Maier, M.B, Amarasinghe, K.D, Clark, C.M, Nichols, R. | Deposit date: | 2006-05-13 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg.Med.Chem.Lett., 16, 2006
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