2H04

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

Summary for 2H04

Entry DOI	10.2210/pdb2h04/pdb
Related	2HO2 2HO3
Descriptor	Protein tyrosine phosphatase, receptor type, B,, {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (3 entities in total)
Functional Keywords	protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36743.52
Authors	Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M.,Gray, J.L.,Peters, K.G.,Maier, M.B.,Amarasinghe, K.D.,Clark, C.M.,Nichols, R. (deposition date: 2006-05-13, release date: 2006-06-13, Last modification date: 2023-08-30)
Primary citation	Amarasinghe, K.K.,Evdokimov, A.G.,Xu, K.,Clark, C.M.,Maier, M.B.,Srivastava, A.,Colson, A.O.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Pokross, M.E.,Gray, J.L.,Peters, K.G. Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg.Med.Chem.Lett., 16:4252-4256, 2006 Cited by PubMed: 16759857 DOI: 10.1016/j.bmcl.2006.05.074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation