6FBV

Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin

Summary for 6FBV

• Entry DOI: 10.2210/pdb6fbv/pdb
• EMDB information: 4230
• Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (9 entities in total)
• Functional Keywords: lipiarmycin, rna pol, rnap, inhibitor, drug, clostridium difficile, antibiotic, tiacumicin b, ccdc 114782, transcription
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 6
• Total formula weight: 423419.92

Authors

Das, K.,Lin, W.,Ebright, E. (deposition date: 2017-12-19, release date: 2018-02-28, Last modification date: 2019-12-11)

• Primary citation: Lin, W.,Das, K.,Degen, D.,Mazumder, A.,Duchi, D.,Wang, D.,Ebright, Y.W.,Ebright, R.Y.,Sineva, E.,Gigliotti, M.,Srivastava, A.,Mandal, S.,Jiang, Y.,Liu, Y.,Yin, R.,Zhang, Z.,Eng, E.T.,Thomas, D.,Donadio, S.,Zhang, H.,Zhang, C.,Kapanidis, A.N.,Ebright, R.H.; Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).; Mol. Cell, 70:60-71.e15, 2018; PubMed: 29606590; DOI: 10.1016/j.molcel.2018.02.026

Experimental method

ELECTRON MICROSCOPY (3.5 Å)