6FBV
Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA-directed RNA polymerase subunit alpha | polymer | 347 | 37745.3 | 2 | UniProt (P9WGZ1) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha |
| 2 | C (C) | DNA-directed RNA polymerase subunit beta | polymer | 1178 | 130018.8 | 1 | UniProt (P9WGY9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta |
| 3 | D (D) | DNA-directed RNA polymerase subunit beta' | polymer | 1316 | 146969.0 | 1 | UniProt (P9WGY7) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta' |
| 4 | E (E) | DNA-directed RNA polymerase subunit omega | polymer | 110 | 11851.1 | 1 | UniProt (P9WGY5) Pfam (PF01192) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega |
| 5 | F (F) | RNA polymerase sigma factor SigA | polymer | 528 | 57877.2 | 1 | UniProt (P9WGI1) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Sigma-A |
| 6 | G, H (D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | J (D) | Fidaxomicin | non-polymer | 1058.0 | 1 | Chemie (FI8) | |||
| 9 | K (D) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 347 (UniProt: P9WGZ1)
| PDB | External Database | Details |
|---|---|---|
| Leu 3 | Ile 3 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 422206.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1213.2 | |
| All* | Total formula weight | 423419.9 |
