6A1C

Crystal structure of the CK2a1-go289 complex

Summary for 6A1C

Entry DOI	10.2210/pdb6a1c/pdb
Descriptor	Casein kinase II subunit alpha, 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol, SODIUM ION, ... (5 entities in total)
Functional Keywords	ck2a1, inhibitor, complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42534.24
Authors	Kinoshita, T.,Tsuyuguchi, M. (deposition date: 2018-06-07, release date: 2019-03-06, Last modification date: 2023-11-22)
Primary citation	Oshima, T.,Niwa, Y.,Kuwata, K.,Srivastava, A.,Hyoda, T.,Tsuchiya, Y.,Kumagai, M.,Tsuyuguchi, M.,Tamaru, T.,Sugiyama, A.,Ono, N.,Zolboot, N.,Aikawa, Y.,Oishi, S.,Nonami, A.,Arai, F.,Hagihara, S.,Yamaguchi, J.,Tama, F.,Kunisaki, Y.,Yagita, K.,Ikeda, M.,Kinoshita, T.,Kay, S.A.,Itami, K.,Hirota, T. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv, 5:eaau9060-eaau9060, 2019 Cited by PubMed: 30746467 DOI: 10.1126/sciadv.aau9060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation