6A1C

Crystal structure of the CK2a1-go289 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 9NX A 401

Chain	Residue
A	VAL66
A	EDO420
A	EDO425
A	HOH511
A	LYS68
A	PHE113
A	VAL116
A	HIS160
A	MET163
A	ILE174
A	ASP175
A	EDO419

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 402

Chain	Residue
A	GLN36
A	TYR39
A	EDO403
A	EDO404
A	HOH546

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 403

Chain	Residue
A	GLN36
A	TYR39
A	ILE69
A	ASP103
A	NA402
A	EDO406
A	HOH546

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 404

Chain	Residue
A	GLN36
A	ASP37
A	TYR39
A	ILE59
A	NA402
A	EDO405
A	HOH513

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 405

Chain	Residue
A	GLN36
A	ASP37
A	GLU320
A	EDO404
A	HOH633
A	HOH680

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 406

Chain	Residue
A	LEU41
A	ASP103
A	VAL105
A	EDO403
A	HOH546

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 407

Chain	Residue
A	GLY90
A	GLY91
A	PRO92
A	ASN93
A	ILE94
A	HOH502

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 408

Chain	Residue
A	PHE232
A	HOH504
A	HOH509
A	HOH554
A	HOH572

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 409

Chain	Residue
A	TYR50
A	LYS77
A	GLU81
A	HOH518

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 410

Chain	Residue
A	ASN118
A	PRO159
A	VAL162
A	MET163
A	ILE164
A	EDO418
A	EDO419

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 411

Chain	Residue
A	ASN117
A	THR119
A	ASP165
A	HIS166
A	GLU167
A	HOH583
A	HOH617

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 412

Chain	Residue
A	PRO4
A	GLU187
A	ASP205
A	TYR206
A	GLN207
A	MET208
A	HOH519

---

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO A 413

Chain	Residue
A	GLY34
A	ASN35
A	GLN36
A	VAL101
A	LYS102
A	HOH506
A	HOH560

---

site_id	AD5
Number of Residues	7
Details	binding site for residue EDO A 414

Chain	Residue
A	ASN93
A	GLU139
A	ARG169
A	LYS170
A	LEU171
A	ARG172
A	EDO415

---

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO A 415

Chain	Residue
A	PRO92
A	ASN93
A	GLU139
A	LYS142
A	EDO414

---

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO A 416

Chain	Residue
A	ARG228
A	LYS229
A	GLU230
A	HOH599
A	TRP33
A	TYR125

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO A 417

Chain	Residue
A	GLY34
A	ASP99
A	HIS234
A	HIS236
A	HOH567

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 418

Chain	Residue
A	PRO159
A	VAL162
A	MET221
A	EDO410

---

site_id	AE1
Number of Residues	6
Details	binding site for residue EDO A 419

Chain	Residue
A	PRO159
A	HIS160
A	VAL162
A	MET163
A	9NX401
A	EDO410

---

site_id	AE2
Number of Residues	6
Details	binding site for residue EDO A 420

Chain	Residue
A	GLY48
A	LYS49
A	TYR50
A	SER51
A	9NX401
A	HOH576

---

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO A 421

Chain	Residue
A	ASP156
A	LYS158
A	SER194
A	EDO423

---

site_id	AE4
Number of Residues	2
Details	binding site for residue EDO A 422

Chain	Residue
A	SER194
A	ARG195

---

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO A 423

Chain	Residue
A	ARG191
A	ALA193
A	LYS198
A	EDO421

---

site_id	AE6
Number of Residues	6
Details	binding site for residue EDO A 424

Chain	Residue
A	VAL248
A	LEU249
A	ARG278
A	LYS279
A	TRP281
A	HOH516

---

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO A 425

Chain	Residue
A	GLU55
A	HIS115
A	VAL116
A	ASN118
A	9NX401

---

site_id	AE8
Number of Residues	4
Details	binding site for residue EDO A 426

Chain	Residue
A	LYS44
A	PHE54
A	EDO427
A	HOH585

---

site_id	AE9
Number of Residues	5
Details	binding site for residue EDO A 427

Chain	Residue
A	PRO295
A	GLU296
A	ASP299
A	HIS321
A	EDO426

---

site_id	AF1
Number of Residues	3
Details	binding site for residue EDO A 428

Chain	Residue
A	LEU203
A	ASN238
A	ASP256

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK

Chain	Residue	Details
A	LEU45-LYS68

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	285
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---