7EJ9
Alternative crystal structure of mouse Cryptochrome 2 in complex with TH301 compound
Summary for 7EJ9
| Entry DOI | 10.2210/pdb7ej9/pdb |
| Descriptor | Cryptochrome-2, 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide (3 entities in total) |
| Functional Keywords | cry, cry2, cryptochrome, phr, circadian clock protein |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 2 |
| Total formula weight | 118666.36 |
| Authors | Miller, S.A.,Hirota, T. (deposition date: 2021-04-01, release date: 2021-06-23, Last modification date: 2023-11-29) |
| Primary citation | Miller, S.,Srivastava, A.,Nagai, Y.,Aikawa, Y.,Tama, F.,Hirota, T. Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34172584DOI: 10.1073/pnas.2026191118 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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